TY - JOUR
T1 - Monoclonal antibody applications in travel medicine
AU - de Jong, Hanna K.
AU - Grobusch, Martin P.
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2024/12/1
Y1 - 2024/12/1
N2 - For decades, immunoglobulin preparations have been used to prevent or treat infectious diseases. Since only a few years, monoclonal antibody applications (mAbs) are taking flight and are increasingly dominating this field. In 2014, only two mAbs were registered; end of October 2023, more than ten mAbs are registered or have been granted emergency use authorization, and many more are in (pre)clinical phases. Especially the COVID-19 pandemic has generated this surge in licensed monoclonal antibodies, although multiple phase 1 studies were already underway in 2019 for other infectious diseases such as malaria and yellow fever. Monoclonal antibodies could function as prophylaxis (i.e., for the prevention of malaria), or could be used to treat (tropical) infections (i.e., rabies, dengue fever, yellow fever). This review focuses on the discussion of the prospects of, and obstacles for, using mAbs in the prevention and treatment of (tropical) infectious diseases seen in the returning traveler; and provides an update on the mAbs currently being developed for infectious diseases, which could potentially be of interest for travelers.
AB - For decades, immunoglobulin preparations have been used to prevent or treat infectious diseases. Since only a few years, monoclonal antibody applications (mAbs) are taking flight and are increasingly dominating this field. In 2014, only two mAbs were registered; end of October 2023, more than ten mAbs are registered or have been granted emergency use authorization, and many more are in (pre)clinical phases. Especially the COVID-19 pandemic has generated this surge in licensed monoclonal antibodies, although multiple phase 1 studies were already underway in 2019 for other infectious diseases such as malaria and yellow fever. Monoclonal antibodies could function as prophylaxis (i.e., for the prevention of malaria), or could be used to treat (tropical) infections (i.e., rabies, dengue fever, yellow fever). This review focuses on the discussion of the prospects of, and obstacles for, using mAbs in the prevention and treatment of (tropical) infectious diseases seen in the returning traveler; and provides an update on the mAbs currently being developed for infectious diseases, which could potentially be of interest for travelers.
KW - Malaria
KW - Monoclonal antibodies
KW - Prophylaxis
KW - Travelers
KW - Tropical infectious disease
UR - http://www.scopus.com/inward/record.url?scp=85182498410&partnerID=8YFLogxK
U2 - https://doi.org/10.1186/s40794-023-00212-x
DO - https://doi.org/10.1186/s40794-023-00212-x
M3 - Review article
C2 - 38221606
SN - 2055-0936
VL - 10
JO - Tropical Diseases, Travel Medicine and Vaccines
JF - Tropical Diseases, Travel Medicine and Vaccines
IS - 1
M1 - 2
ER -