TY - JOUR
T1 - Mononuclear phagocyte heterogeneity in cancer
T2 - Different subsets and activation states reaching out at the tumor site
AU - Laoui, Damya
AU - Van Overmeire, Eva
AU - Movahedi, Kiavash
AU - Van den Bossche, Jan
AU - Schouppe, Elio
AU - Mommer, Camille
AU - Nikolaou, Alexandros
AU - Morias, Yannick
AU - De Baetselier, Patrick
AU - Van Ginderachter, Jo A.
PY - 2011/11/1
Y1 - 2011/11/1
N2 - Mononuclear phagocytes are amongst the most versatile cells of the body, contributing to tissue genesis and homeostasis and safeguarding the balance between pro- and anti-inflammatory reactions. Accordingly, these cells are notoriously heterogeneous, functioning in distinct differentiation forms (monocytes, MDSC, macrophages, DC) and adopting different activation states in response to a changing microenvironment. Accumulating evidence exists that mononuclear phagocytes contribute to all phases of the cancer process. These cells orchestrate the inflammatory events during de novo carcinogenesis, participate in tumor immunosurveillance, and contribute to the progression of established tumors. At the tumor site, cells such as tumor-associated macrophages (TAM) are confronted with different tumor microenvironments, leading to TAM subsets with specialized functions. A better refinement of the molecular and functional heterogeneity of tumor-associated mononuclear phagocytes might pave the way for novel cancer therapies that directly target these tumor-supporting cells.
AB - Mononuclear phagocytes are amongst the most versatile cells of the body, contributing to tissue genesis and homeostasis and safeguarding the balance between pro- and anti-inflammatory reactions. Accordingly, these cells are notoriously heterogeneous, functioning in distinct differentiation forms (monocytes, MDSC, macrophages, DC) and adopting different activation states in response to a changing microenvironment. Accumulating evidence exists that mononuclear phagocytes contribute to all phases of the cancer process. These cells orchestrate the inflammatory events during de novo carcinogenesis, participate in tumor immunosurveillance, and contribute to the progression of established tumors. At the tumor site, cells such as tumor-associated macrophages (TAM) are confronted with different tumor microenvironments, leading to TAM subsets with specialized functions. A better refinement of the molecular and functional heterogeneity of tumor-associated mononuclear phagocytes might pave the way for novel cancer therapies that directly target these tumor-supporting cells.
KW - Carcinogenesis
KW - Immunosurveillance
KW - Myeloid-derived suppressor cells
KW - Tie2-expressing monocytes
KW - Tumor microenvironment
KW - Tumor progression
KW - Tumor-associated dendritic cells
KW - Tumor-associated macrophages
UR - http://www.scopus.com/inward/record.url?scp=80053224897&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.imbio.2011.06.007
DO - https://doi.org/10.1016/j.imbio.2011.06.007
M3 - Review article
C2 - 21803441
SN - 0171-2985
VL - 216
SP - 1192
EP - 1202
JO - Immunobiology
JF - Immunobiology
IS - 11
ER -