TY - JOUR
T1 - Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia
T2 - An international retrospective study
AU - Hasle, Henrik
AU - Alonzo, Todd A.
AU - Auvrignon, Anne
AU - Behar, Catherine
AU - Chang, Myron
AU - Creutzig, Ursula
AU - Fischer, Alexandra
AU - Forestier, Erik
AU - Fynn, Alcira
AU - Haas, Oskar A.
AU - Harbott, Jochen
AU - Harrison, Christine J.
AU - Heerema, Nyla A.
AU - Van Den Heuvel-Eibrink, Marry M.
AU - Kaspers, Gertjan J.L.
AU - Locatelli, Franco
AU - Noellke, Peter
AU - Polychronopoulou, Sophia
AU - Ravindranath, Yaddanapudi
AU - Razzouk, Bassem
AU - Reinhardt, Dirk
AU - Savva, Natalia N.
AU - Stark, Batia
AU - Suciu, Stefan
AU - Tsukimoto, Ichiro
AU - Webb, David K.
AU - Wojcik, Dorora
AU - Woods, William G.
AU - Zimmermann, Martin
AU - Niemeyer, Charlotte M.
AU - Raimondi, Susana C.
PY - 2007/6/1
Y1 - 2007/6/1
N2 - Monosomy 7 (-7) and deletion 7q [del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in transformation (RAEB-T) and -7 or del(7q) with or without other cytogenetic aberrations [± other]. Karyotypes included -7 (n = 90), -7 other (n = 82), del(7q) (n = 21), and del(7q) other (n = 65). Complete remission (CR) was achieved in fewer patients with -7 ± other compared with del(7q) ± other (61% versus 89%, P < .001). Overall, the 5-year survival rate was 39% (SE, 3%). Survival was superior in del(7q) ± other compared with -7 ± other (51% versus 30%, P < .01). Cytogenetic aberrations considered favorable in AML [t(8;21)(q22;q22), inv(16)(p13q22), t(15;17)(q22;q21), t(9;11)(p22;q23)] (n = 24) were strongly associated with del(7q) and a higher 5-year survival rate compared with del(7q) without favorable cytogenetics (75% versus 46%, P = .03). Patients with -7 and inv(3),-5/del(5q), or +21 had a 5-year survival rate of 5%. Stem cell transplantation analyzed as a time-dependent variable had no impact on overall survival. However, patients not achieving CR had a 31% survival rate after stem cell transplantation. Childhood AML with chromosome 7 aberrations represents a heterogeneous group of disorders with additional cytogenetic aberrations having a major prognostic impact which should be reflected in future riskgroup stratification.
AB - Monosomy 7 (-7) and deletion 7q [del(7q)] are rare in childhood acute myeloid leukemia (AML). We retrospectively collected data on 258 children with AML or refractory anemia with excess blasts in transformation (RAEB-T) and -7 or del(7q) with or without other cytogenetic aberrations [± other]. Karyotypes included -7 (n = 90), -7 other (n = 82), del(7q) (n = 21), and del(7q) other (n = 65). Complete remission (CR) was achieved in fewer patients with -7 ± other compared with del(7q) ± other (61% versus 89%, P < .001). Overall, the 5-year survival rate was 39% (SE, 3%). Survival was superior in del(7q) ± other compared with -7 ± other (51% versus 30%, P < .01). Cytogenetic aberrations considered favorable in AML [t(8;21)(q22;q22), inv(16)(p13q22), t(15;17)(q22;q21), t(9;11)(p22;q23)] (n = 24) were strongly associated with del(7q) and a higher 5-year survival rate compared with del(7q) without favorable cytogenetics (75% versus 46%, P = .03). Patients with -7 and inv(3),-5/del(5q), or +21 had a 5-year survival rate of 5%. Stem cell transplantation analyzed as a time-dependent variable had no impact on overall survival. However, patients not achieving CR had a 31% survival rate after stem cell transplantation. Childhood AML with chromosome 7 aberrations represents a heterogeneous group of disorders with additional cytogenetic aberrations having a major prognostic impact which should be reflected in future riskgroup stratification.
UR - http://www.scopus.com/inward/record.url?scp=34249692501&partnerID=8YFLogxK
U2 - https://doi.org/10.1182/blood-2006-10-051342
DO - https://doi.org/10.1182/blood-2006-10-051342
M3 - Article
C2 - 17299091
SN - 0006-4971
VL - 109
SP - 4641
EP - 4647
JO - Blood
JF - Blood
IS - 11
ER -