Mortality in hereditary antithrombin-III deficiency--1830 to 1989

F. R. Rosendaal; H. Heijboer; E. Briët; H. R. Büller; D. P. Brandjes; K. de Bruin; D. W. Hommes; J. P. Vandenbroucke

doi:https://doi.org/10.1016/0140-6736(91)90867-O

Mortality in hereditary antithrombin-III deficiency--1830 to 1989

F. R. Rosendaal, H. Heijboer, E. Briët, H. R. Büller, D. P. Brandjes, K. de Bruin, D. W. Hommes, J. P. Vandenbroucke

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Abstract

To determine whether antithrombin-III (AT-III) deficiency leads to an excess mortality, we studied 171 individuals from ten families with a proven hereditary deficiency. 73 were classified as certainly deficient either by direct measurement of AT-III concentration or by mendelian inheritance patterns. 98 individuals had a high probability (0.5) of deficiency. The 64 deaths recorded did not exceed those expected for the general population adjusted for age, sex, and calendar period. We suggest that a policy of prophylactic anticoagulation for patients with AT-III deficiency cannot be recommended

Original language	English
Pages (from-to)	260-262
Journal	Lancet
Volume	337
Issue number	8736
DOIs	https://doi.org/10.1016/0140-6736(91)90867-O
Publication status	Published - 1991

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https://doi.org/10.1016/0140-6736(91)90867-O

Cite this

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title = "Mortality in hereditary antithrombin-III deficiency--1830 to 1989",

abstract = "To determine whether antithrombin-III (AT-III) deficiency leads to an excess mortality, we studied 171 individuals from ten families with a proven hereditary deficiency. 73 were classified as certainly deficient either by direct measurement of AT-III concentration or by mendelian inheritance patterns. 98 individuals had a high probability (0.5) of deficiency. The 64 deaths recorded did not exceed those expected for the general population adjusted for age, sex, and calendar period. We suggest that a policy of prophylactic anticoagulation for patients with AT-III deficiency cannot be recommended",

author = "Rosendaal, {F. R.} and H. Heijboer and E. Bri{\"e}t and B{\"u}ller, {H. R.} and Brandjes, {D. P.} and {de Bruin}, K. and Hommes, {D. W.} and Vandenbroucke, {J. P.}",

year = "1991",

doi = "https://doi.org/10.1016/0140-6736(91)90867-O",

language = "English",

volume = "337",

pages = "260--262",

journal = "Lancet",

issn = "0140-6736",

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TY - JOUR

T1 - Mortality in hereditary antithrombin-III deficiency--1830 to 1989

AU - Rosendaal, F. R.

AU - Heijboer, H.

AU - Briët, E.

AU - Büller, H. R.

AU - Brandjes, D. P.

AU - de Bruin, K.

AU - Hommes, D. W.

AU - Vandenbroucke, J. P.

PY - 1991

Y1 - 1991

N2 - To determine whether antithrombin-III (AT-III) deficiency leads to an excess mortality, we studied 171 individuals from ten families with a proven hereditary deficiency. 73 were classified as certainly deficient either by direct measurement of AT-III concentration or by mendelian inheritance patterns. 98 individuals had a high probability (0.5) of deficiency. The 64 deaths recorded did not exceed those expected for the general population adjusted for age, sex, and calendar period. We suggest that a policy of prophylactic anticoagulation for patients with AT-III deficiency cannot be recommended

AB - To determine whether antithrombin-III (AT-III) deficiency leads to an excess mortality, we studied 171 individuals from ten families with a proven hereditary deficiency. 73 were classified as certainly deficient either by direct measurement of AT-III concentration or by mendelian inheritance patterns. 98 individuals had a high probability (0.5) of deficiency. The 64 deaths recorded did not exceed those expected for the general population adjusted for age, sex, and calendar period. We suggest that a policy of prophylactic anticoagulation for patients with AT-III deficiency cannot be recommended

U2 - https://doi.org/10.1016/0140-6736(91)90867-O

DO - https://doi.org/10.1016/0140-6736(91)90867-O

M3 - Article

C2 - 1671110

SN - 0140-6736

VL - 337

SP - 260

EP - 262

JO - Lancet

JF - Lancet

IS - 8736

ER -