TY - JOUR
T1 - Mouse visual cortex contains a region of enhanced spatial resolution
AU - van Beest, Enny H.
AU - Mukherjee, Sreedeep
AU - Kirchberger, Lisa
AU - Schnabel, Ulf H.
AU - van der Togt, Chris
AU - Teeuwen, Rob R.M.
AU - Barsegyan, Areg
AU - Meyer, Arne F.
AU - Poort, Jasper
AU - Roelfsema, Pieter R.
AU - Self, Matthew W.
N1 - Funding Information: We thank the animal caretakers at the Netherlands Institute of Neuroscience for their assistance. We would like to thank Alexander Heimel for his advice and assistance with the electrophysiology setup and Christiaan Levelt for assistance with breeding of the mouse lines. We thank Serge Dumoulin for his advice on analysis of pRF mapping data. The work was supported by NWO (ALW grant 823-02-010) and the European Union’s Horizon 2020 and FP7 Research and Innovation Program (grant agreement 7202070 “Human Brain Project SGA1, SGA2 and SGA3,” ERC grant agreement 339490 “Corti-c_al_gorithms,” and the Erasmus Mundus “NeuroTime” program) and the Stichting Vrienden van het Herseninstituut. A. F. M. was supported by the Radboud Excellence Initiative. J. P. is a Wellcome Trust and Royal Society Sir Henry Dale Fellow (211258/Z/ 18/Z). Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - The representation of space in mouse visual cortex was thought to be relatively uniform. Here we reveal, using population receptive-field (pRF) mapping techniques, that mouse visual cortex contains a region in which pRFs are considerably smaller. This region, the “focea,” represents a location in space in front of, and slightly above, the mouse. Using two-photon imaging we show that the smaller pRFs are due to lower scatter of receptive-fields at the focea and an over-representation of binocular regions of space. We show that receptive-fields of single-neurons in areas LM and AL are smaller at the focea and that mice have improved visual resolution in this region of space. Furthermore, freely moving mice make compensatory eye-movements to hold this region in front of them. Our results indicate that mice have spatial biases in their visual processing, a finding that has important implications for the use of the mouse model of vision.
AB - The representation of space in mouse visual cortex was thought to be relatively uniform. Here we reveal, using population receptive-field (pRF) mapping techniques, that mouse visual cortex contains a region in which pRFs are considerably smaller. This region, the “focea,” represents a location in space in front of, and slightly above, the mouse. Using two-photon imaging we show that the smaller pRFs are due to lower scatter of receptive-fields at the focea and an over-representation of binocular regions of space. We show that receptive-fields of single-neurons in areas LM and AL are smaller at the focea and that mice have improved visual resolution in this region of space. Furthermore, freely moving mice make compensatory eye-movements to hold this region in front of them. Our results indicate that mice have spatial biases in their visual processing, a finding that has important implications for the use of the mouse model of vision.
UR - http://www.scopus.com/inward/record.url?scp=85109037432&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85109037432&partnerID=8YFLogxK
U2 - https://doi.org/10.1038/s41467-021-24311-5
DO - https://doi.org/10.1038/s41467-021-24311-5
M3 - Article
C2 - 34188047
SN - 2041-1723
VL - 12
JO - Nature communications
JF - Nature communications
IS - 1
M1 - 4029
ER -