TY - JOUR
T1 - MRI-assessed regional pulse wave velocity for predicting absence of regional aorta luminal growth in marfan syndrome
AU - Kröner, Eleanore S.J.
AU - Scholte, Arthur J.H.A.
AU - De Koning, Patrick J.H.
AU - Van Den Boogaard, Pieter J.
AU - Kroft, Lucia J.M.
AU - Van Der Geest, Rob J.
AU - Hilhorst-Hofstee, Yvonne
AU - Lamb, Hildo J.
AU - Siebelink, Hans Marc J.
AU - Mulder, Barbara J.M.
AU - Groenink, Maarten
AU - Radonic, Teodora
AU - Van Der Wall, Ernst E.
AU - De Roos, Albert
AU - Reiber, Johan H.C.
AU - Westenberg, Jos J.M.
N1 - Funding Information: Grant support: This study was funded by the Netherlands Heart Foundation (Project 2006B138).
PY - 2013
Y1 - 2013
N2 - Background: In patients with Marfan syndrome (MFS), increased aortic wall stiffening may lead to progressive aortic dilatation. Aortic Pulse Wave Velocity (PWV), a marker of wall stiffness can be assessed regionally, using in-plane multi-directional velocity-encoded MRI. This study examined the diagnostic accuracy of regional PWV for prediction of regional aortic luminal growth during 2-year follow-up in MFS patients. Methods: In twenty-one MFS patients (mean age 36 ± 15 years, 11 male) regional PWV and aortic luminal areas were assessed by 1.5 T MRI. At 2-year follow-up, the incidence of luminal growth, defined as mean luminal diameter increase > 2 mm was determined for five aortic segments (S1, ascending aorta; S2, aortic arch; S3, thoracic descending aorta, S4, supra-renal and S5, infra-renal abdominal aorta). Regional PWV at baseline was considered increased when exceeding age-related normal PWV (healthy volunteers (n = 26; mean age 30 ± 10 years, 15 male)) by two standard-errors. Sensitivity and specificity of regional PWV-testing for prediction of regional luminal growth were determined. Results: Regional PWV at baseline was increased in 17 out of 102 segments (17%). Significant luminal growth at follow-up was reported in 14 segments (14%). The specificity of regional PWV-testing was ≥ 78% for all aortic segments, sensitivity was ≤ 33%. Conclusions: Regional PWV was significantly increased in MFS patients as compared to healthy volunteers within similar age range, in all aortic segments except the ascending aorta. Furthermore, regional PWV-assessment has moderate to high specificity for predicting absence of regional aortic luminal growth for all aortic segments in MFS patients.
AB - Background: In patients with Marfan syndrome (MFS), increased aortic wall stiffening may lead to progressive aortic dilatation. Aortic Pulse Wave Velocity (PWV), a marker of wall stiffness can be assessed regionally, using in-plane multi-directional velocity-encoded MRI. This study examined the diagnostic accuracy of regional PWV for prediction of regional aortic luminal growth during 2-year follow-up in MFS patients. Methods: In twenty-one MFS patients (mean age 36 ± 15 years, 11 male) regional PWV and aortic luminal areas were assessed by 1.5 T MRI. At 2-year follow-up, the incidence of luminal growth, defined as mean luminal diameter increase > 2 mm was determined for five aortic segments (S1, ascending aorta; S2, aortic arch; S3, thoracic descending aorta, S4, supra-renal and S5, infra-renal abdominal aorta). Regional PWV at baseline was considered increased when exceeding age-related normal PWV (healthy volunteers (n = 26; mean age 30 ± 10 years, 15 male)) by two standard-errors. Sensitivity and specificity of regional PWV-testing for prediction of regional luminal growth were determined. Results: Regional PWV at baseline was increased in 17 out of 102 segments (17%). Significant luminal growth at follow-up was reported in 14 segments (14%). The specificity of regional PWV-testing was ≥ 78% for all aortic segments, sensitivity was ≤ 33%. Conclusions: Regional PWV was significantly increased in MFS patients as compared to healthy volunteers within similar age range, in all aortic segments except the ascending aorta. Furthermore, regional PWV-assessment has moderate to high specificity for predicting absence of regional aortic luminal growth for all aortic segments in MFS patients.
KW - Aortic dilatation
KW - Blood Flow
KW - Compliance
KW - MRI
KW - Marfan syndrome
UR - http://www.scopus.com/inward/record.url?scp=84883818669&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.ijcard.2012.08.057
DO - https://doi.org/10.1016/j.ijcard.2012.08.057
M3 - Article
C2 - 23000269
SN - 0167-5273
VL - 167
SP - 2977
EP - 2982
JO - International journal of cardiology
JF - International journal of cardiology
IS - 6
ER -