TY - JOUR
T1 - MRI Visualization of Injectable Ureidopyrimidinone Hydrogelators by Supramolecular Contrast Agent Labeling
AU - Bakker, Maarten H.
AU - Tseng, Cheyenne C. S.
AU - Keizer, Henk M.
AU - Seevinck, Peter R.
AU - Janssen, Henk M.
AU - van Slochteren, Frebus J.
AU - Chamuleau, Steven A. J.
AU - Dankers, Patricia Y. W.
PY - 2018/6/6
Y1 - 2018/6/6
N2 - Information about the in vivo location, shape, degradation, or erosion rate of injected in situ gelating hydrogels can be obtained with magnetic resonance imaging (MRI). Herein, an injectable supramolecular ureidopyrimidinone-based hydrogel (UPy-PEG) is functionalized with a modified Gadolinium(III)-DOTA complex (UPy-Gd) for contrast enhanced MRI. The contrast agent is designed to supramolecularly interact with the hydrogel network to enable high-quality imaging of this hydrogel. The applicability of the approach is demonstrated with successful visualization of the Gd-labeled UPy-PEG hydrogel after targeted intramyocardial catheter injection in a pig heart.
AB - Information about the in vivo location, shape, degradation, or erosion rate of injected in situ gelating hydrogels can be obtained with magnetic resonance imaging (MRI). Herein, an injectable supramolecular ureidopyrimidinone-based hydrogel (UPy-PEG) is functionalized with a modified Gadolinium(III)-DOTA complex (UPy-Gd) for contrast enhanced MRI. The contrast agent is designed to supramolecularly interact with the hydrogel network to enable high-quality imaging of this hydrogel. The applicability of the approach is demonstrated with successful visualization of the Gd-labeled UPy-PEG hydrogel after targeted intramyocardial catheter injection in a pig heart.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85045473686&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29658175
U2 - https://doi.org/10.1002/adhm.201701139
DO - https://doi.org/10.1002/adhm.201701139
M3 - Article
C2 - 29658175
SN - 2192-2640
VL - 7
JO - Advanced healthcare materials
JF - Advanced healthcare materials
IS - 11
M1 - 1701139
ER -