TY - JOUR
T1 - Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
AU - COGENT-Kidney Consortium
AU - EPIC-InterAct Consortium
AU - Understanding Society Scientific Group
AU - Lifelines Cohort
AU - Bentley, Amy R.
AU - Sung, Yun J.
AU - Brown, Michael R.
AU - Winkler, Thomas W.
AU - Kraja, Aldi T.
AU - Ntalla, Ioanna
AU - Schwander, Karen
AU - Chasman, Daniel I.
AU - Lim, Elise
AU - Deng, Xuan
AU - Guo, Xiuqing
AU - Liu, Jingmin
AU - Lu, Yingchang
AU - Cheng, Ching-Yu
AU - Sim, Xueling
AU - Vojinovic, Dina
AU - Huffman, Jennifer E.
AU - Musani, Solomon K.
AU - Li, Changwei
AU - Feitosa, Mary F.
AU - Richard, Melissa A.
AU - Noordam, Raymond
AU - Baker, Jenna
AU - Chen, Guanjie
AU - Aschard, Hugues
AU - Bartz, Traci M.
AU - Ding, Jingzhong
AU - Dorajoo, Rajkumar
AU - Manning, Alisa K.
AU - Rankinen, Tuomo
AU - Smith, Albert V.
AU - Tajuddin, Salman M.
AU - Zhao, Wei
AU - Graff, Mariaelisa
AU - Alver, Maris
AU - Boissel, Mathilde
AU - Chai, Jin Fang
AU - Chen, Xu
AU - Divers, Jasmin
AU - Evangelou, Evangelos
AU - Gao, Chuan
AU - Goel, Anuj
AU - Hagemeijer, Yanick
AU - Harris, Sarah E.
AU - Hartwig, Fernando P.
AU - He, Meian
AU - Horimoto, Andrea R. V. R.
AU - Milaneschi, Yuri
AU - Yuan, Jian-Min
AU - Penninx, Brenda W. J. H.
PY - 2019/4/1
Y1 - 2019/4/1
N2 - The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
AB - The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063914316&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30926973
U2 - https://doi.org/10.1038/s41588-019-0378-y
DO - https://doi.org/10.1038/s41588-019-0378-y
M3 - Article
C2 - 30926973
SN - 1061-4036
VL - 51
SP - 636
EP - 648
JO - Nature Genetics
JF - Nature Genetics
IS - 4
ER -