TY - JOUR
T1 - Multimodal analysis of cortical chemoarchitecture and macroscale fMRI resting-state functional connectivity
AU - van den Heuvel, Martijn P.
AU - Scholtens, Lianne H.
AU - Turk, Elise
AU - Mantini, Dante
AU - Vanduffel, Wim
AU - Feldman Barrett, Lisa
PY - 2016/9/1
Y1 - 2016/9/1
N2 - The cerebral cortex is well known to display a large variation in excitatory and inhibitory chemoarchitecture, but the effect of this variation on global scale functional neural communication and synchronization patterns remains less well understood. Here, we provide evidence of the chemoarchitecture of cortical regions to be associated with large-scale region-to-region resting-state functional connectivity. We assessed the excitatory versus inhibitory chemoarchitecture of cortical areas as an ExIn ratio between receptor density mappings of excitatory (AMPA, M1) and inhibitory (GABAA, M2) receptors, computed on the basis of data collated from pioneering studies of autoradiography mappings as present in literature of the human (2 datasets) and macaque (1 dataset) cortex. Cortical variation in ExIn ratio significantly correlated with total level of functional connectivity as derived from resting-state functional connectivity recordings of cortical areas across all three datasets (human I: P = 0.0004; human II: P = 0.0008; macaque: P = 0.0007), suggesting cortical areas with an overall more excitatory character to show higher levels of intrinsic functional connectivity during resting-state. Our findings are indicative of the microscale chemoarchitecture of cortical regions to be related to resting-state fMRI connectivity patterns at the global system's level of connectome organization. Hum Brain Mapp 37:3103–3113, 2016.
AB - The cerebral cortex is well known to display a large variation in excitatory and inhibitory chemoarchitecture, but the effect of this variation on global scale functional neural communication and synchronization patterns remains less well understood. Here, we provide evidence of the chemoarchitecture of cortical regions to be associated with large-scale region-to-region resting-state functional connectivity. We assessed the excitatory versus inhibitory chemoarchitecture of cortical areas as an ExIn ratio between receptor density mappings of excitatory (AMPA, M1) and inhibitory (GABAA, M2) receptors, computed on the basis of data collated from pioneering studies of autoradiography mappings as present in literature of the human (2 datasets) and macaque (1 dataset) cortex. Cortical variation in ExIn ratio significantly correlated with total level of functional connectivity as derived from resting-state functional connectivity recordings of cortical areas across all three datasets (human I: P = 0.0004; human II: P = 0.0008; macaque: P = 0.0007), suggesting cortical areas with an overall more excitatory character to show higher levels of intrinsic functional connectivity during resting-state. Our findings are indicative of the microscale chemoarchitecture of cortical regions to be related to resting-state fMRI connectivity patterns at the global system's level of connectome organization. Hum Brain Mapp 37:3103–3113, 2016.
KW - chemoarchitecture
KW - connectome
KW - excitatory
KW - fMRI
KW - functional connectivity
KW - inhibitory
KW - receptor
KW - resting-state fMRI
UR - http://www.scopus.com/inward/record.url?scp=84982994337&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982994337&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/hbm.23229
DO - https://doi.org/10.1002/hbm.23229
M3 - Article
C2 - 27207489
SN - 1065-9471
VL - 37
SP - 3103
EP - 3113
JO - Human brain mapping
JF - Human brain mapping
IS - 9
ER -