TY - JOUR
T1 - Multimodality nanotracers for cardiovascular applications
AU - Mulder, Willem J. M.
AU - Cormode, David P.
AU - Hak, Sjoerd
AU - Lobatto, Mark E.
AU - Silvera, Stephane
AU - Fayad, Zahi A.
PY - 2008
Y1 - 2008
N2 - Targeted imaging and therapeutics is becoming a field of prime importance in the study and treatment of cardiovascular disease; it promises to enable early diagnosis, promote improved understanding of pathology, and offer a way to improve therapeutic efficacy. Agents, particularly for cardiovascular disease, have been reported to permit the in vivo imaging, by multiple modalities, of macrophages, vascular targets such as vascular cell adhesion molecule 1, and markers for angiogenesis such as alpha(v)beta(3) integrin. In this Article, we first discuss the general concept of multimodality nanoparticles and then focus in greater depth on their clinical application for molecular imaging and therapy. Lastly, several examples of cardiovascular applications are discussed, including combined imaging and therapy approaches
AB - Targeted imaging and therapeutics is becoming a field of prime importance in the study and treatment of cardiovascular disease; it promises to enable early diagnosis, promote improved understanding of pathology, and offer a way to improve therapeutic efficacy. Agents, particularly for cardiovascular disease, have been reported to permit the in vivo imaging, by multiple modalities, of macrophages, vascular targets such as vascular cell adhesion molecule 1, and markers for angiogenesis such as alpha(v)beta(3) integrin. In this Article, we first discuss the general concept of multimodality nanoparticles and then focus in greater depth on their clinical application for molecular imaging and therapy. Lastly, several examples of cardiovascular applications are discussed, including combined imaging and therapy approaches
U2 - https://doi.org/10.1038/ncpcardio1242
DO - https://doi.org/10.1038/ncpcardio1242
M3 - Article
C2 - 18641599
SN - 1743-4297
VL - 5
SP - S103-S111
JO - Nature clinical practice. Cardiovascular medicine
JF - Nature clinical practice. Cardiovascular medicine
IS - Suppl. 2
ER -