TY - JOUR
T1 - Multimorbidity patterns in older persons and their association with self-reported quality of life and limitations in activities of daily living
AU - TOPICS-MDS Consortium
AU - Lutomski, Jennifer E.
AU - Hoekstra, Trynke
AU - Akker, Marjan van den
AU - Blom, Jeanet
AU - Calderón-Larrañaga, Amaia
AU - Marengoni, Alessandra
AU - Prados-Torres, Alexandra
AU - Olde-Rikkert, Marcel
AU - Melis, Rene
N1 - Funding Information: ZonMw (The Dutch Organization for Health Research and Development; Grant reference: 633400002). The financial sponsor had no role in the design, methods, subject recruitment, data collection, analysis or preparation of this manuscript. The authors thank TOPICS-MDS Consortium members for their contribution to this research. TOPICS-MDS Consortium: Project Group N Bleijenberg (Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Netherlands); JW Blom (Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands); S Metzelthin (CAPHRI School for Public Health and Primary Care, Dept. of Health Services Research, Maastricht University, Netherlands), PFM Krabbe (Department of Epidemiology, University of Groningen, University Medical Center Groningen, Netherlands); RJF Melis (Dept. of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands); ME Muntinga (Department of General Practice and Elderly Care Medicine/EMGO + Institute for Health and Care Research, VU University Medical Center, Amsterdam, Netherlands); EW Steyerberg (Department of Public Health, Erasmus MC University Medical Center, Rotterdam, Netherlands); Steering Committee BM Buurman (Department of Internal Medicine and Geriatrics, Academic Medical Center, Amsterdam, Netherlands), J Gussekloo (Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, Netherlands); HE van der Horst (Department of General Practice and Elderly Care Medicine, EMGO Institute for Health and Care Research, VU University Medical center Amsterdam, Netherlands); MGM Olde-Rikkert, (Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands); SEJA de Rooij (University Center for Geriatric Medicine, University Medical Center, Groningen, Netherlands); JMGA Schols (Department of Family Medicine and Dept. of Health Services Research, CAPHRI School for Public Health and Primary Care, Maastricht University, Maastricht, Netherlands); MJ Schuurmans (Department of Rehabilitation, Nursing Science & Sports, University Medical Center Utrecht, Netherlands); DA Smilde (GENERO Foundation, Rotterdam, Netherlands); Working group member: F Leeuwis (Dept. of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands). Publisher Copyright: © 2023
PY - 2023/12/1
Y1 - 2023/12/1
N2 - Background: As populations age, multimorbidity (the presence of two or more chronic morbidities) is increasingly more common. These evolving demographics demand further research into the identification of morbidity patterns in different settings as well as the longitudinal effects of these patterns. Methods: Prospectively collected data on 12,755 older persons aged 65+ years were derived from The Older Persons and Informal Caregivers Survey Minimum DataSet (TOPICS-MDS, www.topics-mds.eu). Latent class analyses were performed to identify unobserved relationship patterns between morbidities in older persons. Using linear mixed models, the average difference in health-related quality of life (EQ-5D) and general quality of life scores (Cantril's Self Anchoring Ladder) as well as limitations in Activities of Daily Living and Instrumental Activities of Daily Living (ADL/IADL) were examined over a 12-month period. Results: Five multimorbidity patterns were identified: sensory (n = 3882), cardio-metabolic (n = 2627), mental health (n = 920), osteo-articular (n = 4486), and system decline (n = 840). Relative to older persons in the sensory group, multimorbidity patterns did not have a strong effect on health-related quality of life, general quality of life or ADL/IADLs over a one-year period. Conclusions: The observed multimorbidity patterns are similar to others based on different methodologies and study populations. When examining the effect of such patterns on quality of life, the EQ-5D and Cantril's Ladder may be insufficient outcome measures. Further investigations into the prognostic value of morbidity patterns would be of benefit.
AB - Background: As populations age, multimorbidity (the presence of two or more chronic morbidities) is increasingly more common. These evolving demographics demand further research into the identification of morbidity patterns in different settings as well as the longitudinal effects of these patterns. Methods: Prospectively collected data on 12,755 older persons aged 65+ years were derived from The Older Persons and Informal Caregivers Survey Minimum DataSet (TOPICS-MDS, www.topics-mds.eu). Latent class analyses were performed to identify unobserved relationship patterns between morbidities in older persons. Using linear mixed models, the average difference in health-related quality of life (EQ-5D) and general quality of life scores (Cantril's Self Anchoring Ladder) as well as limitations in Activities of Daily Living and Instrumental Activities of Daily Living (ADL/IADL) were examined over a 12-month period. Results: Five multimorbidity patterns were identified: sensory (n = 3882), cardio-metabolic (n = 2627), mental health (n = 920), osteo-articular (n = 4486), and system decline (n = 840). Relative to older persons in the sensory group, multimorbidity patterns did not have a strong effect on health-related quality of life, general quality of life or ADL/IADLs over a one-year period. Conclusions: The observed multimorbidity patterns are similar to others based on different methodologies and study populations. When examining the effect of such patterns on quality of life, the EQ-5D and Cantril's Ladder may be insufficient outcome measures. Further investigations into the prognostic value of morbidity patterns would be of benefit.
KW - ADLs
KW - EQ-5D
KW - Latent class analysis
KW - Multimorbidity
KW - Quality of life
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U2 - https://doi.org/10.1016/j.archger.2023.105134
DO - https://doi.org/10.1016/j.archger.2023.105134
M3 - Article
C2 - 37516060
SN - 0167-4943
VL - 115
SP - 1
EP - 7
JO - Archives of gerontology and geriatrics
JF - Archives of gerontology and geriatrics
M1 - 105134
ER -