TY - JOUR
T1 - Muscle wasting in male TNF-α blocker naïve ankylosing spondylitis patients
T2 - a comparison of gender differences in body composition
AU - Ibáñez Vodnizza, Sebastián
AU - Visman, Ingrid M.
AU - van Denderen, Christiaan
AU - Lems, Willem F.
AU - Jaime, Francisca
AU - Nurmohamed, Michael T.
AU - van der Horst-Bruinsma, Irene E.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Objective: To assess gender differences in body composition (BC) in a cohort of AS patients naïve to TNF-α blockers.Methods: Patients included fulfilled the Modified New York criteria for AS. Demographic information and disease activity measures (ASDAS and BASDAI) were reported. BC was measured by whole body DXA. Body fat percentage (BF%), fat mass index (FMI), fat free mass index (FFMI) and android/gynoid fat ratio were reported and compared between men and women and with the reference population (percentiles).Results: Seventy consecutive patients were included; 60% were men. Demographic variables were similar, except for dyslipidaemia (57.1% of men; 14.3% of women). Women had significantly more fat (BF%, FMI), and less muscle (FFMI) than men, but below the median of the reference population. Male AS patients had a markedly low FFMI (31.7th percentile) compared with the reference population. In the whole group, after multivariate analysis, an ASDAS CRP >3.5 was related to lower fat free mass content. In men, a significant relationship between having a high disease activity (ASDAS, BASDAI) and lower BF% or FMI percentile was found, but in women it was the opposite.Conclusion: Muscle wasting, measured as low FFMI compared with the reference population, was found in male TNF-α blocker naïve AS patients, especially in those with active disease. Women had higher volumes of body fat than men, but near the median of the reference population. The relationships between fat content and disease activity support the complex association between adipose tissue and inflammation.
AB - Objective: To assess gender differences in body composition (BC) in a cohort of AS patients naïve to TNF-α blockers.Methods: Patients included fulfilled the Modified New York criteria for AS. Demographic information and disease activity measures (ASDAS and BASDAI) were reported. BC was measured by whole body DXA. Body fat percentage (BF%), fat mass index (FMI), fat free mass index (FFMI) and android/gynoid fat ratio were reported and compared between men and women and with the reference population (percentiles).Results: Seventy consecutive patients were included; 60% were men. Demographic variables were similar, except for dyslipidaemia (57.1% of men; 14.3% of women). Women had significantly more fat (BF%, FMI), and less muscle (FFMI) than men, but below the median of the reference population. Male AS patients had a markedly low FFMI (31.7th percentile) compared with the reference population. In the whole group, after multivariate analysis, an ASDAS CRP >3.5 was related to lower fat free mass content. In men, a significant relationship between having a high disease activity (ASDAS, BASDAI) and lower BF% or FMI percentile was found, but in women it was the opposite.Conclusion: Muscle wasting, measured as low FFMI compared with the reference population, was found in male TNF-α blocker naïve AS patients, especially in those with active disease. Women had higher volumes of body fat than men, but near the median of the reference population. The relationships between fat content and disease activity support the complex association between adipose tissue and inflammation.
KW - ankylosing spondylitis
KW - body composition
KW - dual-energy X-ray absorptiometry
KW - muscle wasting
UR - http://www.scopus.com/inward/record.url?scp=85030417666&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/rheumatology/kex187
DO - https://doi.org/10.1093/rheumatology/kex187
M3 - Article
C2 - 28605535
SN - 1462-0324
VL - 56
SP - 1566
EP - 1572
JO - Rheumatology (Oxford, England)
JF - Rheumatology (Oxford, England)
IS - 9
ER -