Mutant BRCA1 alleles transmission: different approaches and different biases

Miguel de la Hoya; Hanne Meijers-Heijboer; Juan Manuel Fernández; Orland Díez; Ana Osorio; Carmen Alonso; Inge van Leeuwen; Eduardo Díaz-Rubio; Cees Cornelisse; Javier Benítez; Peter Devilee; Trinidad Caldés

doi:https://doi.org/10.1002/ijc.20541

Mutant BRCA1 alleles transmission: different approaches and different biases

Miguel de la Hoya, Hanne Meijers-Heijboer, Juan Manuel Fernández, Orland Díez, Ana Osorio, Carmen Alonso, Inge van Leeuwen, Eduardo Díaz-Rubio, Cees Cornelisse, Javier Benítez, Peter Devilee, Trinidad Caldés

Human Genetics (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

3 Citations (Scopus)

Abstract

Recently, a non-random transmission of BRCA1 mutant alleles to the off-spring of carriers has been suggested. If confirmed by further studies, the finding will have important implications both for risk assessment and the understanding of BRCA1 biology. However, these kind of analysis are not easy to perform due to several ascertainment biases inherent to the identification of BRCA1 carriers. In this report we propose different approaches to overcome such biases and we present additional data supporting a non-random transmission of BRCA1 mutant alleles

Original language	English
Pages (from-to)	166-167
Journal	International journal of cancer. Journal international du cancer
Volume	113
Issue number	1
DOIs	https://doi.org/10.1002/ijc.20541
Publication status	Published - 2005

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https://doi.org/10.1002/ijc.20541

Cite this

de la Hoya, M., Meijers-Heijboer, H., Fernández, J. M., Díez, O., Osorio, A., Alonso, C., van Leeuwen, I., Díaz-Rubio, E., Cornelisse, C., Benítez, J., Devilee, P., & Caldés, T. (2005). Mutant BRCA1 alleles transmission: different approaches and different biases. International journal of cancer. Journal international du cancer, 113(1), 166-167. https://doi.org/10.1002/ijc.20541

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abstract = "Recently, a non-random transmission of BRCA1 mutant alleles to the off-spring of carriers has been suggested. If confirmed by further studies, the finding will have important implications both for risk assessment and the understanding of BRCA1 biology. However, these kind of analysis are not easy to perform due to several ascertainment biases inherent to the identification of BRCA1 carriers. In this report we propose different approaches to overcome such biases and we present additional data supporting a non-random transmission of BRCA1 mutant alleles",

author = "{de la Hoya}, Miguel and Hanne Meijers-Heijboer and Fern{\'a}ndez, {Juan Manuel} and Orland D{\'i}ez and Ana Osorio and Carmen Alonso and {van Leeuwen}, Inge and Eduardo D{\'i}az-Rubio and Cees Cornelisse and Javier Ben{\'i}tez and Peter Devilee and Trinidad Cald{\'e}s",

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de la Hoya, M, Meijers-Heijboer, H, Fernández, JM, Díez, O, Osorio, A, Alonso, C, van Leeuwen, I, Díaz-Rubio, E, Cornelisse, C, Benítez, J, Devilee, P & Caldés, T 2005, 'Mutant BRCA1 alleles transmission: different approaches and different biases', International journal of cancer. Journal international du cancer, vol. 113, no. 1, pp. 166-167. https://doi.org/10.1002/ijc.20541

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T1 - Mutant BRCA1 alleles transmission: different approaches and different biases

AU - de la Hoya, Miguel

AU - Meijers-Heijboer, Hanne

AU - Fernández, Juan Manuel

AU - Díez, Orland

AU - Osorio, Ana

AU - Alonso, Carmen

AU - van Leeuwen, Inge

AU - Díaz-Rubio, Eduardo

AU - Cornelisse, Cees

AU - Benítez, Javier

AU - Devilee, Peter

AU - Caldés, Trinidad

PY - 2005

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N2 - Recently, a non-random transmission of BRCA1 mutant alleles to the off-spring of carriers has been suggested. If confirmed by further studies, the finding will have important implications both for risk assessment and the understanding of BRCA1 biology. However, these kind of analysis are not easy to perform due to several ascertainment biases inherent to the identification of BRCA1 carriers. In this report we propose different approaches to overcome such biases and we present additional data supporting a non-random transmission of BRCA1 mutant alleles

AB - Recently, a non-random transmission of BRCA1 mutant alleles to the off-spring of carriers has been suggested. If confirmed by further studies, the finding will have important implications both for risk assessment and the understanding of BRCA1 biology. However, these kind of analysis are not easy to perform due to several ascertainment biases inherent to the identification of BRCA1 carriers. In this report we propose different approaches to overcome such biases and we present additional data supporting a non-random transmission of BRCA1 mutant alleles

U2 - https://doi.org/10.1002/ijc.20541

DO - https://doi.org/10.1002/ijc.20541

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