TY - JOUR
T1 - Myopic presentation of central serous chorioretinopathy
AU - Ravenstijn, Monica
AU - van Dijk, Elon H. C.
AU - Haarman, Annechien E. G.
AU - Kaden, Talia R.
AU - Vermeer, Koenraad A.
AU - Boon, Camiel J. F.
AU - Yannuzzi, Lawrence A.
AU - Klaver, Caroline C. W.
AU - Yzer, Suzanne
N1 - Funding Information: Supported by Rotterdamse Stichting Blindenbelangen (RSB), Rotterdam, the Netherlands. B20170076. The sponsor had no role in the design or conduct of this research. Publisher Copyright: © 2021 Lippincott Williams and Wilkins. All rights reserved.
PY - 2021/12/1
Y1 - 2021/12/1
N2 - Purpose: To increase insight into the myopic presentation of central serous chorioretinopathy (CSC) by comparing a large group of myopic patients with CSC with reference groups with only one of the diagnoses. Methods: Myopic patients with CSC (spherical equivalent #23D, n = 46), emmetropic patients with CSC (spherical equivalent 20.5 to 0.5 D, n = 83), and myopic, non-CSC patients (n = 50) were included in this multicenter cross-sectional study. Disease characteristics and imaging parameters, such as subfoveal choroidal thickness and indocyanine green angiography patterns, were compared between cases and reference groups. Results: In myopic patients with CSC, median subfoveal choroidal thickness (286 mm [IQR 226-372 mm]) was significantly thicker than subfoveal choroidal thickness in myopic, non-CSC patients (200 mm [IQR 152-228 mm], P , 0.001) but thinner than emmetropic patients with CSC (452 mm [IQR 342-538 mm], P , 0.001). They also had pachyvessels in 70% of the eyes comparable with emmetropic CSC (76%, P = 0.70). Choroidal hyperpermeability was frequently present on indocyanine green angiography in both myopic and emmetropic CSC eyes. Need for treatment, treatment success, and recurrence rate were not significantly different between CSC groups. Conclusion: Myopic CSC presents with similar imaging and clinical characteristics as emmetropic CSC, apart from their thinner choroids. Keeping in mind the structural changes of myopia, other imaging characteristics could aid the diagnostic process.
AB - Purpose: To increase insight into the myopic presentation of central serous chorioretinopathy (CSC) by comparing a large group of myopic patients with CSC with reference groups with only one of the diagnoses. Methods: Myopic patients with CSC (spherical equivalent #23D, n = 46), emmetropic patients with CSC (spherical equivalent 20.5 to 0.5 D, n = 83), and myopic, non-CSC patients (n = 50) were included in this multicenter cross-sectional study. Disease characteristics and imaging parameters, such as subfoveal choroidal thickness and indocyanine green angiography patterns, were compared between cases and reference groups. Results: In myopic patients with CSC, median subfoveal choroidal thickness (286 mm [IQR 226-372 mm]) was significantly thicker than subfoveal choroidal thickness in myopic, non-CSC patients (200 mm [IQR 152-228 mm], P , 0.001) but thinner than emmetropic patients with CSC (452 mm [IQR 342-538 mm], P , 0.001). They also had pachyvessels in 70% of the eyes comparable with emmetropic CSC (76%, P = 0.70). Choroidal hyperpermeability was frequently present on indocyanine green angiography in both myopic and emmetropic CSC eyes. Need for treatment, treatment success, and recurrence rate were not significantly different between CSC groups. Conclusion: Myopic CSC presents with similar imaging and clinical characteristics as emmetropic CSC, apart from their thinner choroids. Keeping in mind the structural changes of myopia, other imaging characteristics could aid the diagnostic process.
KW - Central serous chorioretinopathy
KW - Choroidal thickness
KW - Indocyanine green angiography
KW - Myopia
KW - Pachychoroid
KW - Pachyvessels
UR - http://www.scopus.com/inward/record.url?scp=85120550496&partnerID=8YFLogxK
U2 - https://doi.org/10.1097/IAE.0000000000003297
DO - https://doi.org/10.1097/IAE.0000000000003297
M3 - Article
C2 - 34483315
SN - 0275-004X
VL - 41
SP - 2472
EP - 2478
JO - Retina (Philadelphia, Pa.)
JF - Retina (Philadelphia, Pa.)
IS - 12
ER -