TY - JOUR
T1 - N-terminal B-type natriuretic peptide urinary concentrations and retinopathy of prematurity
AU - Bührer, Christoph
AU - Erdeve, Ömer
AU - van Kaam, Anton
AU - Berger, Angelika
AU - Lechner, Evelyn
AU - Bar-Oz, Benjamin
AU - Allegaert, Karel
AU - Stiris, Tom
AU - Çelik, İstemi Han
AU - Berrington, Janet
PY - 2017
Y1 - 2017
N2 - BACKGROUND: To validate the findings of a single-center pilot study showing elevated urinary N-terminal B-type natriuretic peptide (NTproBNP) concentrations in preterm infants subsequently developing severe retinopathy of prematurity (ROP) in a multicenter setting across eight European and Middle East countries. METHODS: Prospective observational study in 967 preterm infants <30 weeks' gestational age assessing the capacity of urinary NTproBNP on days of life (DOLs) 14 and 28 to predict ROP requiring treatment. RESULTS: Urinary NTproBNP concentrations were markedly elevated in infants who developed ROP requiring treatment (n = 94) compared with survivors without ROP treatment (n = 837), at both time points (median (interquartile range) DOL14: 8,950 (1,925-23,783) vs. 3,083 (1,193-17,393) vs. 816 (290-3,078) pg/ml, P <0.001) and DOL28 (2,203 (611-4,063) vs. 1,671 (254-11,340) vs. 408 (162-1,126) pg/ml, P <0.001). C-statistic of NTproBNP for treated ROP or death was 0.731 (95% confidence interval 0.654-0.774) for DOL14 and 0.683 (0.622-0.745) for DOL28 (P <0.001). Threshold scores were calculated, potentially enabling around 20% of infants with low NTproBNP scores never to be screened with ophthalmoscopy. CONCLUSION: There is a strong association between early urinary NTproBNP and subsequent ROP development, which can be used to further refine subgroups of patients with high or low risk of severe ROP
AB - BACKGROUND: To validate the findings of a single-center pilot study showing elevated urinary N-terminal B-type natriuretic peptide (NTproBNP) concentrations in preterm infants subsequently developing severe retinopathy of prematurity (ROP) in a multicenter setting across eight European and Middle East countries. METHODS: Prospective observational study in 967 preterm infants <30 weeks' gestational age assessing the capacity of urinary NTproBNP on days of life (DOLs) 14 and 28 to predict ROP requiring treatment. RESULTS: Urinary NTproBNP concentrations were markedly elevated in infants who developed ROP requiring treatment (n = 94) compared with survivors without ROP treatment (n = 837), at both time points (median (interquartile range) DOL14: 8,950 (1,925-23,783) vs. 3,083 (1,193-17,393) vs. 816 (290-3,078) pg/ml, P <0.001) and DOL28 (2,203 (611-4,063) vs. 1,671 (254-11,340) vs. 408 (162-1,126) pg/ml, P <0.001). C-statistic of NTproBNP for treated ROP or death was 0.731 (95% confidence interval 0.654-0.774) for DOL14 and 0.683 (0.622-0.745) for DOL28 (P <0.001). Threshold scores were calculated, potentially enabling around 20% of infants with low NTproBNP scores never to be screened with ophthalmoscopy. CONCLUSION: There is a strong association between early urinary NTproBNP and subsequent ROP development, which can be used to further refine subgroups of patients with high or low risk of severe ROP
U2 - https://doi.org/10.1038/pr.2017.179
DO - https://doi.org/10.1038/pr.2017.179
M3 - Article
C2 - 28738027
SN - 0031-3998
VL - 82
SP - 958
EP - 963
JO - Pediatric Research
JF - Pediatric Research
IS - 6
ER -