TY - JOUR
T1 - NAFLD is related to Post-prandial Triglyceride-enrichment of HDL Particles in Association with Endothelial and HDL Dysfunction
AU - Verwer, Bart J.
AU - Scheffer, Peter G.
AU - Vermue, Rick P.
AU - Pouwels, Petra J.
AU - Diamant, Michaela
AU - Tushuizen, Maarten E.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - NAFLD is closely related with the metabolic syndrome (MetS) and increased risk of cardiovascular disease. Liver fat associates with post-prandial hypertriglyceridemia, potentially contributing to triglyceride-enrichment of high-density lipoproteins (HDL-TG), and subsequent HDL dysfunction. We assessed liver fat by MR spectroscopy, and its association with HDL physiochemical properties, and endothelial function, measured as flow-mediated dilation (FMD), before and following three consecutive meals, in 36 men with type 2 diabetes mellitus (T2DM), with the MetS, and controls. Plasma triglycerides increased significantly following the meals (P <.001). Fasting HDL-TG was highest in T2DM, relative to MetS and controls (P =.002), and increased post-prandially in all groups (P <.001). HDL function was negatively associated with HDL-TG following three meals (r = −.32, P<.05). Liver fat associated with HDL-TG after three meals (r =.65, P <.001). HDL-TG was independently associated with FMD following three consecutive meals (r = −.477, P =.003). We conclude liver fat is associated with post-prandial HDL-TG enrichment which was closely related with endothelial and HDL dysfunction.
AB - NAFLD is closely related with the metabolic syndrome (MetS) and increased risk of cardiovascular disease. Liver fat associates with post-prandial hypertriglyceridemia, potentially contributing to triglyceride-enrichment of high-density lipoproteins (HDL-TG), and subsequent HDL dysfunction. We assessed liver fat by MR spectroscopy, and its association with HDL physiochemical properties, and endothelial function, measured as flow-mediated dilation (FMD), before and following three consecutive meals, in 36 men with type 2 diabetes mellitus (T2DM), with the MetS, and controls. Plasma triglycerides increased significantly following the meals (P <.001). Fasting HDL-TG was highest in T2DM, relative to MetS and controls (P =.002), and increased post-prandially in all groups (P <.001). HDL function was negatively associated with HDL-TG following three meals (r = −.32, P<.05). Liver fat associated with HDL-TG after three meals (r =.65, P <.001). HDL-TG was independently associated with FMD following three consecutive meals (r = −.477, P =.003). We conclude liver fat is associated with post-prandial HDL-TG enrichment which was closely related with endothelial and HDL dysfunction.
KW - HDL
KW - NAFLD - post-prandial dyslipidemia - type 2 diabetes
KW - metabolic syndrome
UR - http://www.scopus.com/inward/record.url?scp=85088424120&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/liv.14597
DO - https://doi.org/10.1111/liv.14597
M3 - Article
C2 - 32652824
SN - 1478-3223
VL - 40
SP - 2439
EP - 2444
JO - Liver international
JF - Liver international
IS - 10
ER -