Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform

David P. Cormode; Torjus Skajaa; Matti M. van Schooneveld; Rolf Koole; Peter Jarzyna; Mark E. Lobatto; Claudia Calcagno; Alessandra Barazza; Ronald E. Gordon; Pat Zanzonico; Edward A. Fisher; Zahi A. Fayad; Willem J. M. Mulder

doi:https://doi.org/10.1021/nl801958b

Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform

David P. Cormode, Torjus Skajaa, Matti M. van Schooneveld, Rolf Koole, Peter Jarzyna, Mark E. Lobatto, Claudia Calcagno, Alessandra Barazza, Ronald E. Gordon, Pat Zanzonico, Edward A. Fisher, Zahi A. Fayad, Willem J. M. Mulder

Research output: Contribution to journal › Article › Academic › peer-review

307 Citations (Scopus)

Abstract

High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by incorporation of gold, iron oxide, or quantum dot nanocrystals for computed tomography, magnetic resonance, and fluorescence imaging, respectively. By including additional labels in the corona of the particles, they were made multifunctional. The characteristics of these nanoparticles, as well as their in vitro and in vivo behavior, revealed that they closely mimic native HDL

Original language	English
Pages (from-to)	3715-3723
Journal	Nano letters
Volume	8
Issue number	11
DOIs	https://doi.org/10.1021/nl801958b
Publication status	Published - 2008

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https://doi.org/10.1021/nl801958b

Cite this

@article{5d4de12fdbe04e54b96fc02f250c37ea,

title = "Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform",

abstract = "High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by incorporation of gold, iron oxide, or quantum dot nanocrystals for computed tomography, magnetic resonance, and fluorescence imaging, respectively. By including additional labels in the corona of the particles, they were made multifunctional. The characteristics of these nanoparticles, as well as their in vitro and in vivo behavior, revealed that they closely mimic native HDL",

author = "Cormode, {David P.} and Torjus Skajaa and {van Schooneveld}, {Matti M.} and Rolf Koole and Peter Jarzyna and Lobatto, {Mark E.} and Claudia Calcagno and Alessandra Barazza and Gordon, {Ronald E.} and Pat Zanzonico and Fisher, {Edward A.} and Fayad, {Zahi A.} and Mulder, {Willem J. M.}",

year = "2008",

doi = "https://doi.org/10.1021/nl801958b",

language = "English",

volume = "8",

pages = "3715--3723",

journal = "Nano letters",

issn = "1530-6984",

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T1 - Nanocrystal core high-density lipoproteins: a multimodality contrast agent platform

AU - Cormode, David P.

AU - Skajaa, Torjus

AU - van Schooneveld, Matti M.

AU - Koole, Rolf

AU - Jarzyna, Peter

AU - Lobatto, Mark E.

AU - Calcagno, Claudia

AU - Barazza, Alessandra

AU - Gordon, Ronald E.

AU - Zanzonico, Pat

AU - Fisher, Edward A.

AU - Fayad, Zahi A.

AU - Mulder, Willem J. M.

PY - 2008

Y1 - 2008

N2 - High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by incorporation of gold, iron oxide, or quantum dot nanocrystals for computed tomography, magnetic resonance, and fluorescence imaging, respectively. By including additional labels in the corona of the particles, they were made multifunctional. The characteristics of these nanoparticles, as well as their in vitro and in vivo behavior, revealed that they closely mimic native HDL

AB - High density lipoprotein (HDL) is an important natural nanoparticle that may be modified for biomedical imaging purposes. Here we developed a novel technique to create unique multimodality HDL mimicking nanoparticles by incorporation of gold, iron oxide, or quantum dot nanocrystals for computed tomography, magnetic resonance, and fluorescence imaging, respectively. By including additional labels in the corona of the particles, they were made multifunctional. The characteristics of these nanoparticles, as well as their in vitro and in vivo behavior, revealed that they closely mimic native HDL

U2 - https://doi.org/10.1021/nl801958b

DO - https://doi.org/10.1021/nl801958b

M3 - Article

C2 - 18939808

SN - 1530-6984

VL - 8

SP - 3715

EP - 3723

JO - Nano letters

JF - Nano letters

IS - 11

ER -