Nanoparticles as magnetic resonance imaging contrast agents for vascular and cardiac diseases

Wei Chen; David P. Cormode; Zahi A. Fayad; Willem J. M. Mulder

doi:https://doi.org/10.1002/wnan.114

Nanoparticles as magnetic resonance imaging contrast agents for vascular and cardiac diseases

Wei Chen, David P. Cormode, Zahi A. Fayad, Willem J. M. Mulder

Medical Biochemistry (AMC)

Research output: Contribution to journal › Review article › Academic › peer-review

49 Citations (Scopus)

Abstract

Advances in nanoparticle contrast agents for molecular imaging have made magnetic resonance imaging a promising modality for noninvasive visualization and assessment of vascular and cardiac disease processes. This review provides a description of the various nanoparticles exploited for imaging cardiovascular targets. Nanoparticle probes detecting inflammation, apoptosis, extracellular matrix, and angiogenesis may provide tools for assessing the risk of progressive vascular dysfunction and heart failure. The utility of nanoparticles as multimodal probes and/or theranostic agents has also been investigated. Although clinical application of these nanoparticles is largely unexplored, the potential for enhancing disease diagnosis and treatment is considerable. WIREs Nanomed Nanobiotechnol 2010 DOI: 10.1002/wnan.114For further resources related to this article, please visit the WIREs website

Original language	English
Pages (from-to)	146-161
Journal	Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
Volume	3
Issue number	2
DOIs	https://doi.org/10.1002/wnan.114
Publication status	Published - 2011

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https://doi.org/10.1002/wnan.114

Cite this

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title = "Nanoparticles as magnetic resonance imaging contrast agents for vascular and cardiac diseases",

abstract = "Advances in nanoparticle contrast agents for molecular imaging have made magnetic resonance imaging a promising modality for noninvasive visualization and assessment of vascular and cardiac disease processes. This review provides a description of the various nanoparticles exploited for imaging cardiovascular targets. Nanoparticle probes detecting inflammation, apoptosis, extracellular matrix, and angiogenesis may provide tools for assessing the risk of progressive vascular dysfunction and heart failure. The utility of nanoparticles as multimodal probes and/or theranostic agents has also been investigated. Although clinical application of these nanoparticles is largely unexplored, the potential for enhancing disease diagnosis and treatment is considerable. WIREs Nanomed Nanobiotechnol 2010 DOI: 10.1002/wnan.114For further resources related to this article, please visit the WIREs website",

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AU - Cormode, David P.

AU - Fayad, Zahi A.

AU - Mulder, Willem J. M.

PY - 2011

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AB - Advances in nanoparticle contrast agents for molecular imaging have made magnetic resonance imaging a promising modality for noninvasive visualization and assessment of vascular and cardiac disease processes. This review provides a description of the various nanoparticles exploited for imaging cardiovascular targets. Nanoparticle probes detecting inflammation, apoptosis, extracellular matrix, and angiogenesis may provide tools for assessing the risk of progressive vascular dysfunction and heart failure. The utility of nanoparticles as multimodal probes and/or theranostic agents has also been investigated. Although clinical application of these nanoparticles is largely unexplored, the potential for enhancing disease diagnosis and treatment is considerable. WIREs Nanomed Nanobiotechnol 2010 DOI: 10.1002/wnan.114For further resources related to this article, please visit the WIREs website

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