TY - JOUR
T1 - Narrow-band imaging for the detection of polyps in patients with serrated polyposis syndrome: a multicenter, randomized, back-to-back trial
AU - Hazewinkel, Yark
AU - Tytgat, Kristien M. A. J.
AU - van Leerdam, Monique E.
AU - Koornstra, Jan-Jacob
AU - Bastiaansen, Barbara A.
AU - van Eeden, Susanne
AU - Fockens, Paul
AU - Dekker, Evelien
PY - 2015
Y1 - 2015
N2 - Serrated polyposis syndrome (SPS) is characterized by the presence of multiple serrated polyps spread throughout the colon. Patients with SPS are considered to be at risk of colorectal cancer and are advised to undergo endoscopic surveillance. Narrow-band imaging (NBI) may improve the detection of polyps during these surveillance colonoscopies. To compare polyp miss rates between NBI and high-resolution white-light endoscopy (HR-WLE). Multicenter, randomized, crossover study. Four tertiary referral institutions. A total of 52 patients with SPS undergoing surveillance colonoscopy. All patients underwent back-to-back colonoscopies with HR-WLE and NBI in a randomized order. Polyp miss rates of HR-WLE and NBI. In the HR-WLE group, 116 polyps were detected during the first inspection. A second inspection with NBI added 47 polyps, resulting in an overall polyp miss rate of 29% with HR-WLE (95% confidence interval, 22-36). In the NBI group, a total of 128 polyps were detected during the first inspection. Subsequent inspection with HR-WLE added 32 polyps, resulting in an overall polyp miss rate of NBI of 20% (95% confidence interval, 15-27). Comparison of the overall polyp miss rates of HR-WLE and NBI showed no significant difference (P = .065). Small sample size; second inspection was performed by the same endoscopist. The results of our study suggest that NBI does not reduce polyp miss rates in patients with SPS compared with HR-WLE. Further multinational studies with larger numbers of patients are warranted to verify these results. ( NTR2497.)
AB - Serrated polyposis syndrome (SPS) is characterized by the presence of multiple serrated polyps spread throughout the colon. Patients with SPS are considered to be at risk of colorectal cancer and are advised to undergo endoscopic surveillance. Narrow-band imaging (NBI) may improve the detection of polyps during these surveillance colonoscopies. To compare polyp miss rates between NBI and high-resolution white-light endoscopy (HR-WLE). Multicenter, randomized, crossover study. Four tertiary referral institutions. A total of 52 patients with SPS undergoing surveillance colonoscopy. All patients underwent back-to-back colonoscopies with HR-WLE and NBI in a randomized order. Polyp miss rates of HR-WLE and NBI. In the HR-WLE group, 116 polyps were detected during the first inspection. A second inspection with NBI added 47 polyps, resulting in an overall polyp miss rate of 29% with HR-WLE (95% confidence interval, 22-36). In the NBI group, a total of 128 polyps were detected during the first inspection. Subsequent inspection with HR-WLE added 32 polyps, resulting in an overall polyp miss rate of NBI of 20% (95% confidence interval, 15-27). Comparison of the overall polyp miss rates of HR-WLE and NBI showed no significant difference (P = .065). Small sample size; second inspection was performed by the same endoscopist. The results of our study suggest that NBI does not reduce polyp miss rates in patients with SPS compared with HR-WLE. Further multinational studies with larger numbers of patients are warranted to verify these results. ( NTR2497.)
U2 - https://doi.org/10.1016/j.gie.2014.06.043
DO - https://doi.org/10.1016/j.gie.2014.06.043
M3 - Article
C2 - 25088921
SN - 0016-5107
VL - 81
SP - 531
EP - 538
JO - Gastrointestinal Endoscopy
JF - Gastrointestinal Endoscopy
IS - 3
ER -