Near-infrared fluorescence energy transfer imaging of nanoparticle accumulation and dissociation kinetics in tumor-bearing mice

Yiming Zhao; Inge van Rooy; Sjoerd Hak; Francois Fay; Jun Tang; Catharina de Lange Davies; Mihaela Skobe; Edward Allen Fisher; Aurelian Radu; Zahi A. Fayad; Celso de Mello Donegá; Andries Meijerink; Willem J. M. Mulder

doi:https://doi.org/10.1021/nn404782p

Near-infrared fluorescence energy transfer imaging of nanoparticle accumulation and dissociation kinetics in tumor-bearing mice

Yiming Zhao, Inge van Rooy, Sjoerd Hak, Francois Fay, Jun Tang, Catharina de Lange Davies, Mihaela Skobe, Edward Allen Fisher, Aurelian Radu, Zahi A. Fayad, Celso de Mello Donegá, Andries Meijerink, Willem J. M. Mulder

Research output: Contribution to journal › Article › Academic › peer-review

57 Citations (Scopus)

Abstract

In the current study we show the dissociation and tumor accumulation dynamics of dual-labeled near-infrared quantum dot core self-assembled lipidic nanoparticles (SALNPs) in a mouse model upon intravenous administration. Using advanced in vivo fluorescence energy transfer imaging techniques, we observed swift exchange with plasma protein components in the blood and progressive SALNP dissociation and subsequent trafficking of individual SALNP components following tumor accumulation. Our results suggest that upon intravenous administration SALNPs quickly transform, which may affect their functionality. The presented technology provides a modular in vivo tool to visualize SALNP behavior in real time and may contribute to improving the therapeutic outcome or molecular imaging signature of SALNPs

Original language	English
Pages (from-to)	10362-10370
Journal	ACS nano
Volume	7
Issue number	11
DOIs	https://doi.org/10.1021/nn404782p
Publication status	Published - 2013

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https://doi.org/10.1021/nn404782p

Cite this

Zhao, Y., van Rooy, I., Hak, S., Fay, F., Tang, J., Davies, C. D. L., Skobe, M., Fisher, E. A., Radu, A., Fayad, Z. A., de Mello Donegá, C., Meijerink, A., & Mulder, W. J. M. (2013). Near-infrared fluorescence energy transfer imaging of nanoparticle accumulation and dissociation kinetics in tumor-bearing mice. ACS nano, 7(11), 10362-10370. https://doi.org/10.1021/nn404782p

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title = "Near-infrared fluorescence energy transfer imaging of nanoparticle accumulation and dissociation kinetics in tumor-bearing mice",

abstract = "In the current study we show the dissociation and tumor accumulation dynamics of dual-labeled near-infrared quantum dot core self-assembled lipidic nanoparticles (SALNPs) in a mouse model upon intravenous administration. Using advanced in vivo fluorescence energy transfer imaging techniques, we observed swift exchange with plasma protein components in the blood and progressive SALNP dissociation and subsequent trafficking of individual SALNP components following tumor accumulation. Our results suggest that upon intravenous administration SALNPs quickly transform, which may affect their functionality. The presented technology provides a modular in vivo tool to visualize SALNP behavior in real time and may contribute to improving the therapeutic outcome or molecular imaging signature of SALNPs",

author = "Yiming Zhao and {van Rooy}, Inge and Sjoerd Hak and Francois Fay and Jun Tang and Davies, {Catharina de Lange} and Mihaela Skobe and Fisher, {Edward Allen} and Aurelian Radu and Fayad, {Zahi A.} and {de Mello Doneg{\'a}}, Celso and Andries Meijerink and Mulder, {Willem J. M.}",

year = "2013",

doi = "https://doi.org/10.1021/nn404782p",

language = "English",

volume = "7",

pages = "10362--10370",

journal = "ACS nano",

issn = "1936-0851",

publisher = "American Chemical Society",

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T1 - Near-infrared fluorescence energy transfer imaging of nanoparticle accumulation and dissociation kinetics in tumor-bearing mice

AU - Zhao, Yiming

AU - van Rooy, Inge

AU - Hak, Sjoerd

AU - Fay, Francois

AU - Tang, Jun

AU - Davies, Catharina de Lange

AU - Skobe, Mihaela

AU - Fisher, Edward Allen

AU - Radu, Aurelian

AU - Fayad, Zahi A.

AU - de Mello Donegá, Celso

AU - Meijerink, Andries

AU - Mulder, Willem J. M.

PY - 2013

Y1 - 2013

N2 - In the current study we show the dissociation and tumor accumulation dynamics of dual-labeled near-infrared quantum dot core self-assembled lipidic nanoparticles (SALNPs) in a mouse model upon intravenous administration. Using advanced in vivo fluorescence energy transfer imaging techniques, we observed swift exchange with plasma protein components in the blood and progressive SALNP dissociation and subsequent trafficking of individual SALNP components following tumor accumulation. Our results suggest that upon intravenous administration SALNPs quickly transform, which may affect their functionality. The presented technology provides a modular in vivo tool to visualize SALNP behavior in real time and may contribute to improving the therapeutic outcome or molecular imaging signature of SALNPs

AB - In the current study we show the dissociation and tumor accumulation dynamics of dual-labeled near-infrared quantum dot core self-assembled lipidic nanoparticles (SALNPs) in a mouse model upon intravenous administration. Using advanced in vivo fluorescence energy transfer imaging techniques, we observed swift exchange with plasma protein components in the blood and progressive SALNP dissociation and subsequent trafficking of individual SALNP components following tumor accumulation. Our results suggest that upon intravenous administration SALNPs quickly transform, which may affect their functionality. The presented technology provides a modular in vivo tool to visualize SALNP behavior in real time and may contribute to improving the therapeutic outcome or molecular imaging signature of SALNPs

U2 - https://doi.org/10.1021/nn404782p

DO - https://doi.org/10.1021/nn404782p

M3 - Article

C2 - 24134041

SN - 1936-0851

VL - 7

SP - 10362

EP - 10370

JO - ACS nano

JF - ACS nano

IS - 11

ER -