TY - JOUR
T1 - Nelfinavir plasma concentrations are low during pregnancy
AU - Nellen, Jeannine F. J. B.
AU - Schillevoort, Igor
AU - Wit, Ferdinand W. N. M.
AU - Bergshoeff, Alina S.
AU - Godfried, Mieke H.
AU - Boer, Kees
AU - Lange, Joep M. A.
AU - Burger, David M.
AU - Prins, Jan M.
PY - 2004
Y1 - 2004
N2 - Plasma nelfinavir concentration ratios (CRs) were calculated for all pregnant (n=27) and nonpregnant (n=48) human immunodeficiency virus type 1-infected women receiving the drug who visited our outpatient clinic. In pregnant women, mean and median nelfinavir CRs were significantly lower (P=.02 and P=.04, respectively), and 51% of the CRs were below the clinically relevant threshold of 0.90, compared with 35% of the CRs in nonpregnant women. After we adjusted for confounders, we found that the mean nelfinavir CR was 34% lower in pregnant women (P=.02). With targeted interventions, subsequent CRs in pregnant women showed a significant increase (median increase, 0.31; P=.01)
AB - Plasma nelfinavir concentration ratios (CRs) were calculated for all pregnant (n=27) and nonpregnant (n=48) human immunodeficiency virus type 1-infected women receiving the drug who visited our outpatient clinic. In pregnant women, mean and median nelfinavir CRs were significantly lower (P=.02 and P=.04, respectively), and 51% of the CRs were below the clinically relevant threshold of 0.90, compared with 35% of the CRs in nonpregnant women. After we adjusted for confounders, we found that the mean nelfinavir CR was 34% lower in pregnant women (P=.02). With targeted interventions, subsequent CRs in pregnant women showed a significant increase (median increase, 0.31; P=.01)
U2 - https://doi.org/10.1086/422719
DO - https://doi.org/10.1086/422719
M3 - Article
C2 - 15356791
SN - 1058-4838
VL - 39
SP - 736
EP - 740
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 5
ER -