Neuroendocrine regulation of salivary IgA synthesis and secretion: implications for oral health

Wijnand Teeuw; Jos A Bosch; Enno C I Veerman; Arie V Nieuw Amerongen

doi:https://doi.org/10.1515/BC.2004.147

Neuroendocrine regulation of salivary IgA synthesis and secretion: implications for oral health

Wijnand Teeuw, Jos A Bosch, Enno C I Veerman, Arie V Nieuw Amerongen

Research output: Contribution to journal › Review article › Academic › peer-review

Abstract

Secretory immunoglobulin A (S-IgA) represents the main adaptive immune mechanism in the oral cavity. The regulation of secretion and synthesis of S-IgA is not only dependent on prior antigenic stimulation, but is also under strong neuroendocrine control. Thus, alterations in neuroendocrine functioning (such as induced by stress, exercise, pregnancy, menstrual cycle, and pharmacological interventions) may affect salivary IgA levels. This review deals with the neuroendocrine regulation of synthesis and secretion of salivary IgA and its potential role in the maintenance of oral health.

Original language	English
Pages (from-to)	1137-46
Number of pages	10
Journal	Biological chemistry
Volume	385
Issue number	12
DOIs	https://doi.org/10.1515/BC.2004.147
Publication status	Published - Dec 2004

Keywords

Animals
Dental Caries/immunology
Humans
Immunoglobulin A, Secretory/chemistry
Mouth/microbiology
Neurosecretory Systems/physiology
Oral Health
Saliva/metabolism

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https://doi.org/10.1515/BC.2004.147

Cite this

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title = "Neuroendocrine regulation of salivary IgA synthesis and secretion: implications for oral health",

abstract = "Secretory immunoglobulin A (S-IgA) represents the main adaptive immune mechanism in the oral cavity. The regulation of secretion and synthesis of S-IgA is not only dependent on prior antigenic stimulation, but is also under strong neuroendocrine control. Thus, alterations in neuroendocrine functioning (such as induced by stress, exercise, pregnancy, menstrual cycle, and pharmacological interventions) may affect salivary IgA levels. This review deals with the neuroendocrine regulation of synthesis and secretion of salivary IgA and its potential role in the maintenance of oral health.",

keywords = "Animals, Dental Caries/immunology, Humans, Immunoglobulin A, Secretory/chemistry, Mouth/microbiology, Neurosecretory Systems/physiology, Oral Health, Saliva/metabolism",

author = "Wijnand Teeuw and Bosch, {Jos A} and Veerman, {Enno C I} and Amerongen, {Arie V Nieuw}",

year = "2004",

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AU - Teeuw, Wijnand

AU - Bosch, Jos A

AU - Veerman, Enno C I

AU - Amerongen, Arie V Nieuw

PY - 2004/12

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AB - Secretory immunoglobulin A (S-IgA) represents the main adaptive immune mechanism in the oral cavity. The regulation of secretion and synthesis of S-IgA is not only dependent on prior antigenic stimulation, but is also under strong neuroendocrine control. Thus, alterations in neuroendocrine functioning (such as induced by stress, exercise, pregnancy, menstrual cycle, and pharmacological interventions) may affect salivary IgA levels. This review deals with the neuroendocrine regulation of synthesis and secretion of salivary IgA and its potential role in the maintenance of oral health.

KW - Animals

KW - Dental Caries/immunology

KW - Humans

KW - Immunoglobulin A, Secretory/chemistry

KW - Mouth/microbiology

KW - Neurosecretory Systems/physiology

KW - Oral Health

KW - Saliva/metabolism

U2 - https://doi.org/10.1515/BC.2004.147

DO - https://doi.org/10.1515/BC.2004.147

M3 - Review article

C2 - 15653426

SN - 1431-6730

VL - 385

SP - 1137

EP - 1146

JO - Biological chemistry

JF - Biological chemistry

IS - 12

ER -