Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology

J J M Hoozemans; R Veerhuis; J M Rozemuller; P Eikelenboom

doi:https://doi.org/10.1016/j.ijdevneu.2005.11.001

Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology

J J M Hoozemans, R Veerhuis, J M Rozemuller, P Eikelenboom

Research output: Contribution to journal › Article › Academic › peer-review

163 Citations (Scopus)

Abstract

The initial stages of Alzheimer's disease pathology in the neocortex show upregulation of cell cycle proteins, adhesion and inflammation related factors, indicating the early involvement of inflammatory and regenerating pathways in Alzheimer's disease pathogenesis. These brain changes precede the neurofibrillary pathology and the extensive process of neurodestruction and (astro)gliosis. Amyloid beta deposition, inflammation and regenerative mechanisms are also early pathogenic events in transgenic mouse models harbouring the pathological Alzheimer's disease mutations, while neurodegenerative characteristics are not seen in these models. This review will discuss the relationship between neuroinflammation and neuroregeneration in the early stages of Alzheimer's disease pathogenesis.

Original language	English
Pages (from-to)	157-65
Number of pages	9
Journal	International journal of developmental neuroscience
Volume	24
Issue number	2-3
DOIs	https://doi.org/10.1016/j.ijdevneu.2005.11.001
Publication status	Published - 31 Dec 2005

Keywords

Alzheimer Disease
Amyloid beta-Peptides
Animals
Animals, Genetically Modified
Disease Models, Animal
Encephalitis
Humans
Journal Article
Models, Biological
Regeneration
Research Support, Non-U.S. Gov't
Review

Access to Document

https://doi.org/10.1016/j.ijdevneu.2005.11.001

Cite this

@article{c4b4f3830438467da31de03b971db3e9,

title = "Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology",

abstract = "The initial stages of Alzheimer's disease pathology in the neocortex show upregulation of cell cycle proteins, adhesion and inflammation related factors, indicating the early involvement of inflammatory and regenerating pathways in Alzheimer's disease pathogenesis. These brain changes precede the neurofibrillary pathology and the extensive process of neurodestruction and (astro)gliosis. Amyloid beta deposition, inflammation and regenerative mechanisms are also early pathogenic events in transgenic mouse models harbouring the pathological Alzheimer's disease mutations, while neurodegenerative characteristics are not seen in these models. This review will discuss the relationship between neuroinflammation and neuroregeneration in the early stages of Alzheimer's disease pathogenesis.",

keywords = "Alzheimer Disease, Amyloid beta-Peptides, Animals, Animals, Genetically Modified, Disease Models, Animal, Encephalitis, Humans, Journal Article, Models, Biological, Regeneration, Research Support, Non-U.S. Gov't, Review",

author = "Hoozemans, {J J M} and R Veerhuis and Rozemuller, {J M} and P Eikelenboom",

year = "2005",

month = dec,

day = "31",

doi = "https://doi.org/10.1016/j.ijdevneu.2005.11.001",

language = "English",

volume = "24",

pages = "157--65",

journal = "International journal of developmental neuroscience",

issn = "0736-5748",

publisher = "Elsevier Limited",

number = "2-3",

}

TY - JOUR

T1 - Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology

AU - Hoozemans, J J M

AU - Veerhuis, R

AU - Rozemuller, J M

AU - Eikelenboom, P

PY - 2005/12/31

Y1 - 2005/12/31

N2 - The initial stages of Alzheimer's disease pathology in the neocortex show upregulation of cell cycle proteins, adhesion and inflammation related factors, indicating the early involvement of inflammatory and regenerating pathways in Alzheimer's disease pathogenesis. These brain changes precede the neurofibrillary pathology and the extensive process of neurodestruction and (astro)gliosis. Amyloid beta deposition, inflammation and regenerative mechanisms are also early pathogenic events in transgenic mouse models harbouring the pathological Alzheimer's disease mutations, while neurodegenerative characteristics are not seen in these models. This review will discuss the relationship between neuroinflammation and neuroregeneration in the early stages of Alzheimer's disease pathogenesis.

AB - The initial stages of Alzheimer's disease pathology in the neocortex show upregulation of cell cycle proteins, adhesion and inflammation related factors, indicating the early involvement of inflammatory and regenerating pathways in Alzheimer's disease pathogenesis. These brain changes precede the neurofibrillary pathology and the extensive process of neurodestruction and (astro)gliosis. Amyloid beta deposition, inflammation and regenerative mechanisms are also early pathogenic events in transgenic mouse models harbouring the pathological Alzheimer's disease mutations, while neurodegenerative characteristics are not seen in these models. This review will discuss the relationship between neuroinflammation and neuroregeneration in the early stages of Alzheimer's disease pathogenesis.

KW - Alzheimer Disease

KW - Amyloid beta-Peptides

KW - Animals

KW - Animals, Genetically Modified

KW - Disease Models, Animal

KW - Encephalitis

KW - Humans

KW - Journal Article

KW - Models, Biological

KW - Regeneration

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - https://doi.org/10.1016/j.ijdevneu.2005.11.001

DO - https://doi.org/10.1016/j.ijdevneu.2005.11.001

M3 - Article

C2 - 16384684

SN - 0736-5748

VL - 24

SP - 157

EP - 165

JO - International journal of developmental neuroscience

JF - International journal of developmental neuroscience

IS - 2-3

ER -