TY - CHAP
T1 - Neuroinflammation
T2 - From target selection to preclinical and clinical studies
AU - Zinnhardt, Bastian
AU - Barca, Cristina
AU - Foray, Claudia
AU - Fricke, Inga B.
AU - Viel, Thomas
AU - Winkeler, Alexandra
AU - Windhorst, Albert D.
AU - Jacobs, Andreas H.
PY - 2020/9/29
Y1 - 2020/9/29
N2 - Inflammation is a highly dynamic and complex adaptive process to preserve and restore tissue homeostasis in neurological disorders and often serves as a prognostic marker for disease outcome. The underlying cellular and factorial heterogeneity represents an opportunity in the development of disease-modifying therapies. Molecular imaging of neuroinflammation (NI) may support the characterization of key aspects of the dynamic interplay of various inducers, sensors, transducers, and effectors of the multifactorial inflammatory response in vivo in animal models and patients. The characterization of the NI response by molecular imaging will (i) support early diagnosis and disease follow-up, (ii) guide (stereotactic) biopsy sampling, (iii) highlight the dynamic changes during disease pathogenesis in a noninvasive manner, (iv) help monitoring existing therapies, (v) support the development of novel NI-modifying therapies, and (vi) aid stratification of patients, according to their individual NI profile. This book chapter will review the basic principles of NI, recent developments and applications of novel molecular imaging targets, key considerations for the selection and development of imaging targets, as well as examples of successful clinical translation of NI imaging.
AB - Inflammation is a highly dynamic and complex adaptive process to preserve and restore tissue homeostasis in neurological disorders and often serves as a prognostic marker for disease outcome. The underlying cellular and factorial heterogeneity represents an opportunity in the development of disease-modifying therapies. Molecular imaging of neuroinflammation (NI) may support the characterization of key aspects of the dynamic interplay of various inducers, sensors, transducers, and effectors of the multifactorial inflammatory response in vivo in animal models and patients. The characterization of the NI response by molecular imaging will (i) support early diagnosis and disease follow-up, (ii) guide (stereotactic) biopsy sampling, (iii) highlight the dynamic changes during disease pathogenesis in a noninvasive manner, (iv) help monitoring existing therapies, (v) support the development of novel NI-modifying therapies, and (vi) aid stratification of patients, according to their individual NI profile. This book chapter will review the basic principles of NI, recent developments and applications of novel molecular imaging targets, key considerations for the selection and development of imaging targets, as well as examples of successful clinical translation of NI imaging.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85099969070&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/36119653
U2 - https://doi.org/10.1007/978-3-030-53176-8_17
DO - https://doi.org/10.1007/978-3-030-53176-8_17
M3 - Chapter
C2 - 36119653
SN - 9783030531751
T3 - PET and SPECT of Neurobiological Systems
SP - 567
EP - 592
BT - PET and SPECT of Neurobiological Systems
PB - Springer International Publishing
ER -