TY - JOUR
T1 - Neuroinflammation
T2 - Microglia and T Cells Get Ready to Tango
AU - Schetters, Sjoerd T. T.
AU - Gomez-Nicola, Diego
AU - Garcia-Vallejo, Juan J.
AU - van Kooyk, Yvette
PY - 2018
Y1 - 2018
N2 - In recent years, many paradigms concerning central nervous system (CNS) immunology have been challenged and shifted, including the discovery of CNS-draining lymphatic vessels, the origin and functional diversity of microglia, the impact of T cells on CNS immunological homeostasis and the role of neuroinflammation in neurodegenerative diseases. In parallel, antigen presentation outside the CNS has revealed the vital role of antigen-presenting cells in maintaining tolerance toward self-proteins, thwarting auto-immunity. Here, we review recent findings that unite these shifted paradigms of microglial functioning, antigen presentation, and CNS-directed T cell activation, focusing on common neurodegenerative diseases. It provides an important update on CNS adaptive immunity, novel targets, and a concept of the microglia T-cell equilibrium.
AB - In recent years, many paradigms concerning central nervous system (CNS) immunology have been challenged and shifted, including the discovery of CNS-draining lymphatic vessels, the origin and functional diversity of microglia, the impact of T cells on CNS immunological homeostasis and the role of neuroinflammation in neurodegenerative diseases. In parallel, antigen presentation outside the CNS has revealed the vital role of antigen-presenting cells in maintaining tolerance toward self-proteins, thwarting auto-immunity. Here, we review recent findings that unite these shifted paradigms of microglial functioning, antigen presentation, and CNS-directed T cell activation, focusing on common neurodegenerative diseases. It provides an important update on CNS adaptive immunity, novel targets, and a concept of the microglia T-cell equilibrium.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85041117455&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29422891
U2 - https://doi.org/10.3389/fimmu.2017.01905
DO - https://doi.org/10.3389/fimmu.2017.01905
M3 - Article
C2 - 29422891
SN - 1664-3224
VL - 8
JO - Frontiers in immunology
JF - Frontiers in immunology
IS - JAN
M1 - 1905
ER -