Neuronal expression of caspase-1 immunoreactivity in the rat central nervous system

Catharina Lindberg, Charlotta Eriksson, Anne-Marie Van Dam, Bengt Winblad, Marianne Schultzberg

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Caspase-1/interleukin-1beta (IL-1beta)-converting enzyme (ICE) cleaves IL-1beta and IL-18 precursor proteins to the active forms of these proinflammatory cytokines. Since both cytokines are constitutively expressed in the brain, we investigated whether this is also the case for caspase-1. Using an antibody raised against the p10-subunit of the active enzyme, constitutive expression of caspase-1 immunoreactivity was found in nerve cells in the arcuate nucleus and in nerve fibres throughout the brain. Co-localisation with alpha-melanocyte stimulating hormone was demonstrated. The distribution pattern of caspase-1 immunoreactive structures is consistent with a role to produce mature IL-1beta in regions where IL-1beta mediates fever and sleep.

Original languageEnglish
Pages (from-to)99-113
Number of pages15
JournalJournal of Neuroimmunology
Issue number1-2
Publication statusPublished - Jan 2004


  • Animals
  • Brain
  • Caspase 1
  • Central Nervous System
  • Gene Expression Regulation, Enzymologic
  • Humans
  • Immunohistochemistry
  • Journal Article
  • Male
  • Neurons
  • Rats
  • Rats, Sprague-Dawley
  • Research Support, Non-U.S. Gov't

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