TY - JOUR
T1 - Neutrophil Migratory Patterns
T2 - Implications for Cardiovascular Disease
AU - Dahdah, Albert
AU - Johnson, Jillian
AU - Gopalkrishna, Sreejit
AU - Jaggers, Robert M.
AU - Webb, Darren
AU - Murphy, Andrew J.
AU - Hanssen, Nordin M. J.
AU - Hanaoka, Beatriz Y.
AU - Nagareddy, Prabhakara R.
N1 - Funding Information: PN is supported by grants from the NIH (R01HL13779, R21AG063197) and the startup funds from the Department of Surgery, OSU. NH is supported by a DFN-DON grant 2020 (2020.10.002). BH is supported by funds from the NIH (K23AR068450). Publisher Copyright: Copyright © 2022 Dahdah, Johnson, Gopalkrishna, Jaggers, Webb, Murphy, Hanssen, Hanaoka and Nagareddy.
PY - 2022/3/2
Y1 - 2022/3/2
N2 - The body’s inflammatory response involves a series of processes that are necessary for the immune system to mitigate threats from invading pathogens. Leukocyte migration is a crucial process in both homeostatic and inflammatory states. The mechanisms involved in immune cell recruitment to the site of inflammation are numerous and require several cascades and cues of activation. Immune cells have multiple origins and can be recruited from primary and secondary lymphoid, as well as reservoir organs within the body to generate an immune response to certain stimuli. However, no matter the origin, an important aspect of any inflammatory response is the web of networks that facilitates immune cell trafficking. The vasculature is an important organ for this trafficking, especially during an inflammatory response, mainly because it allows cells to migrate towards the source of insult/injury and serves as a reservoir for leukocytes and granulocytes under steady state conditions. One of the most active and vital leukocytes in the immune system’s arsenal are neutrophils. Neutrophils exist under two forms in the vasculature: a marginated pool that is attached to the vessel walls, and a demarginated pool that freely circulates within the blood stream. In this review, we seek to present the current consensus on the mechanisms involved in leukocyte margination and demargination, with a focus on the role of neutrophil migration patterns during physio-pathological conditions, in particular diabetes and cardiovascular disease.
AB - The body’s inflammatory response involves a series of processes that are necessary for the immune system to mitigate threats from invading pathogens. Leukocyte migration is a crucial process in both homeostatic and inflammatory states. The mechanisms involved in immune cell recruitment to the site of inflammation are numerous and require several cascades and cues of activation. Immune cells have multiple origins and can be recruited from primary and secondary lymphoid, as well as reservoir organs within the body to generate an immune response to certain stimuli. However, no matter the origin, an important aspect of any inflammatory response is the web of networks that facilitates immune cell trafficking. The vasculature is an important organ for this trafficking, especially during an inflammatory response, mainly because it allows cells to migrate towards the source of insult/injury and serves as a reservoir for leukocytes and granulocytes under steady state conditions. One of the most active and vital leukocytes in the immune system’s arsenal are neutrophils. Neutrophils exist under two forms in the vasculature: a marginated pool that is attached to the vessel walls, and a demarginated pool that freely circulates within the blood stream. In this review, we seek to present the current consensus on the mechanisms involved in leukocyte margination and demargination, with a focus on the role of neutrophil migration patterns during physio-pathological conditions, in particular diabetes and cardiovascular disease.
KW - cardiovasclar disease
KW - catecholamine stress
KW - demargination
KW - margination
KW - migration
KW - neutrophils
UR - http://www.scopus.com/inward/record.url?scp=85126825393&partnerID=8YFLogxK
U2 - https://doi.org/10.3389/fcell.2022.795784
DO - https://doi.org/10.3389/fcell.2022.795784
M3 - Review article
C2 - 35309915
SN - 2296-634X
VL - 10
JO - Frontiers in cell and developmental biology
JF - Frontiers in cell and developmental biology
M1 - 795784
ER -