TY - JOUR
T1 - Neutrophils in cardiovascular disease
T2 - warmongers, peacemakers, or both?
AU - Sreejit, Gopalkrishna
AU - Johnson, Jillian
AU - Jaggers, Robert M.
AU - Dahdah, Albert
AU - Murphy, Andrew J.
AU - Hanssen, Nordin M. J.
AU - Nagareddy, Prabhakara R.
N1 - Publisher Copyright: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.
PY - 2022/9/20
Y1 - 2022/9/20
N2 - Neutrophils, the most abundant of all leucocytes and the first cells to arrive at the sites of sterile inflammation/injury act as a double-edged sword. On one hand, they inflict a significant collateral damage to the tissues and on the other hand, they help facilitate wound healing by a number of mechanisms. Recent studies have drastically changed the perception of neutrophils from being simple one-dimensional cells with an unrestrained mode of action to a cell type that display maturity and complex behaviour. It is now recognized that neutrophils are transcriptionally active and respond to plethora of signals by deploying a wide variety of cargo to influence the activity of other cells in the vicinity. Neutrophils can regulate macrophage behaviour, display innate immune memory, and play a major role in the resolution of inflammation in a context-dependent manner. In this review, we provide an update on the factors that regulate neutrophil production and the emerging dichotomous role of neutrophils in the context of cardiovascular diseases, particularly in atherosclerosis and the ensuing complications, myocardial infarction, and heart failure. Deciphering the complex behaviour of neutrophils during inflammation and resolution may provide novel insights and in turn facilitate the development of potential therapeutic strategies to manage cardiovascular disease.
AB - Neutrophils, the most abundant of all leucocytes and the first cells to arrive at the sites of sterile inflammation/injury act as a double-edged sword. On one hand, they inflict a significant collateral damage to the tissues and on the other hand, they help facilitate wound healing by a number of mechanisms. Recent studies have drastically changed the perception of neutrophils from being simple one-dimensional cells with an unrestrained mode of action to a cell type that display maturity and complex behaviour. It is now recognized that neutrophils are transcriptionally active and respond to plethora of signals by deploying a wide variety of cargo to influence the activity of other cells in the vicinity. Neutrophils can regulate macrophage behaviour, display innate immune memory, and play a major role in the resolution of inflammation in a context-dependent manner. In this review, we provide an update on the factors that regulate neutrophil production and the emerging dichotomous role of neutrophils in the context of cardiovascular diseases, particularly in atherosclerosis and the ensuing complications, myocardial infarction, and heart failure. Deciphering the complex behaviour of neutrophils during inflammation and resolution may provide novel insights and in turn facilitate the development of potential therapeutic strategies to manage cardiovascular disease.
KW - Atherosclerosis
KW - Inflammation
KW - Myeolopoiesis
KW - Myocardial infarction
KW - Neutrophils
UR - http://www.scopus.com/inward/record.url?scp=85126809730&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/cvr/cvab302
DO - https://doi.org/10.1093/cvr/cvab302
M3 - Review article
C2 - 34534269
SN - 0008-6363
VL - 118
SP - 2596
EP - 2609
JO - Cardiovascular research
JF - Cardiovascular research
IS - 12
ER -