TY - JOUR
T1 - New statistical technique for analyzing MIC-based susceptibility data
AU - van de Kassteele, Jan
AU - van Santen-Verheuvel, Marga G.
AU - Koedijk, Femke D. H.
AU - van Dam, Alje P.
AU - van der Sande, Marianne A. B.
AU - de Neeling, Albert J.
PY - 2012
Y1 - 2012
N2 - Seventeen laboratories participated in a cooperative study to validate the regional susceptibility testing of Neisseria gonorrhoeae in The Netherlands. International reference strains were distributed. Each laboratory determined the MICs of ciprofloxacin, penicillin, and tetracycline, for each strain by Etest. To explore a more transparent assessment of quality and comparability, a statistical regression model was fitted to the data that accounted for the censoring of the MICs. The mean MICs found by all of the laboratories except three were closer than one 2-fold dilution step to the overall mean, and the mean MICs of each antimicrobial agent were close to the MICs for the international reference strains. This approach provided an efficient tool to analyze the performance of the Dutch decentralized gonococcal resistance monitoring system and confirmed good and comparable standards. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
AB - Seventeen laboratories participated in a cooperative study to validate the regional susceptibility testing of Neisseria gonorrhoeae in The Netherlands. International reference strains were distributed. Each laboratory determined the MICs of ciprofloxacin, penicillin, and tetracycline, for each strain by Etest. To explore a more transparent assessment of quality and comparability, a statistical regression model was fitted to the data that accounted for the censoring of the MICs. The mean MICs found by all of the laboratories except three were closer than one 2-fold dilution step to the overall mean, and the mean MICs of each antimicrobial agent were close to the MICs for the international reference strains. This approach provided an efficient tool to analyze the performance of the Dutch decentralized gonococcal resistance monitoring system and confirmed good and comparable standards. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84857173434&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/22232288
U2 - https://doi.org/10.1128/AAC.05777-11
DO - https://doi.org/10.1128/AAC.05777-11
M3 - Article
C2 - 22232288
SN - 0066-4804
VL - 56
SP - 1557
EP - 1563
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 3
ER -