Nieuwe inzichten in de immunologie rond HIV. Het verloop van de infectie

S. Kostense; D. Van Baarle; M. Hazenberg; F. Miedema

Nieuwe inzichten in de immunologie rond HIV. Het verloop van de infectie

Translated title of the contribution: The course of the infection. New insights into immunology concerning HIV

S. Kostense, D. Van Baarle, M. Hazenberg, F. Miedema

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

HIV infection enhances immune activation, which causes accelerated T cell proliferation and apoptosis resulting in depletion of CD₄-positive T cells. In addition, pathogen-activated CD₄-positive T cells are preferentially infected and are selectively lost. CD8-positive T cells require CD₄-positive T cell help for optimal elimination of infected cells, but CD8-positive T cells lacking help of CD₄-positive T cells do not differentiate into effector cells and have impaired effector function. In the absence of functional CD8-positive T cells, opportunistic infections can not be controlled, which leads to aids.

Translated title of the contribution	The course of the infection. New insights into immunology concerning HIV
Original language	Dutch
Pages (from-to)	158-161
Number of pages	4
Journal	Pharmaceutisch Weekblad
Volume	136
Issue number	5
Publication status	Published - 2 Feb 2001

Keywords

Aids-related opportunistic infections
Allergy and immunology
CD-positive T-lymphocytes
CD8-positive T-lymphocytes
HIV
Infection

Cite this

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abstract = "HIV infection enhances immune activation, which causes accelerated T cell proliferation and apoptosis resulting in depletion of CD4-positive T cells. In addition, pathogen-activated CD4-positive T cells are preferentially infected and are selectively lost. CD8-positive T cells require CD4-positive T cell help for optimal elimination of infected cells, but CD8-positive T cells lacking help of CD4-positive T cells do not differentiate into effector cells and have impaired effector function. In the absence of functional CD8-positive T cells, opportunistic infections can not be controlled, which leads to aids.",

keywords = "Aids-related opportunistic infections, Allergy and immunology, CD-positive T-lymphocytes, CD8-positive T-lymphocytes, HIV, Infection",

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AU - Kostense, S.

AU - Van Baarle, D.

AU - Hazenberg, M.

AU - Miedema, F.

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AB - HIV infection enhances immune activation, which causes accelerated T cell proliferation and apoptosis resulting in depletion of CD4-positive T cells. In addition, pathogen-activated CD4-positive T cells are preferentially infected and are selectively lost. CD8-positive T cells require CD4-positive T cell help for optimal elimination of infected cells, but CD8-positive T cells lacking help of CD4-positive T cells do not differentiate into effector cells and have impaired effector function. In the absence of functional CD8-positive T cells, opportunistic infections can not be controlled, which leads to aids.

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KW - Allergy and immunology

KW - CD-positive T-lymphocytes

KW - CD8-positive T-lymphocytes

KW - HIV

KW - Infection

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JO - Pharmaceutisch Weekblad

JF - Pharmaceutisch Weekblad

IS - 5

ER -

Nieuwe inzichten in de immunologie rond HIV. Het verloop van de infectie

Abstract

Keywords

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