No apparent local effect of insulin on microdialysis continuous glucose-monitoring measurements

Jeroen Hermanides; Iris M. Wentholt; Augustinus A. Hart; Joost B. Hoekstra; J. Hans DeVries

doi:https://doi.org/10.2337/dc08-0145

No apparent local effect of insulin on microdialysis continuous glucose-monitoring measurements

Jeroen Hermanides, Iris M. Wentholt, Augustinus A. Hart, Joost B. Hoekstra, J. Hans DeVries

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

OBJECTIVE - Data investigating the possible disturbing influence of insulin in the vicinity of continuous glucose monitoring (CGM) is lacking. We investigated the hypothesis that high local insulin concentrations would interfere with sensor readings. RESEARCH DESIGN AND METHODS - Two microdialysis sensors were inserted in the periumbilical region of 10 continuous subcutaneous insulin infusion (CSII)-treated type I patients. A test sensor was inserted as close as possible to the insulin catheter and compared with a control sensor. Glucose peak and nadir were induced. Horizontal and vertical shifts were assessed using curve fitting, and mean absolute difference (MAD) between paired blood and sensor values were calculated. RESULTS - Curve fitting showed no significant differences between the two sensors. MAD +/- SD was 8.50 +/- 3.47% for the test sensor and 9.21 +/- 3.17% for the control sensor, P = 0.72. CONCLUSIONS - Microdialysis CGM can be accurately performed in the proximity of CSII systems

Original language	English
Pages (from-to)	1120-1122
Journal	Diabetes Care
Volume	31
Issue number	6
DOIs	https://doi.org/10.2337/dc08-0145
Publication status	Published - 2008

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https://doi.org/10.2337/dc08-0145

Cite this

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title = "No apparent local effect of insulin on microdialysis continuous glucose-monitoring measurements",

abstract = "OBJECTIVE - Data investigating the possible disturbing influence of insulin in the vicinity of continuous glucose monitoring (CGM) is lacking. We investigated the hypothesis that high local insulin concentrations would interfere with sensor readings. RESEARCH DESIGN AND METHODS - Two microdialysis sensors were inserted in the periumbilical region of 10 continuous subcutaneous insulin infusion (CSII)-treated type I patients. A test sensor was inserted as close as possible to the insulin catheter and compared with a control sensor. Glucose peak and nadir were induced. Horizontal and vertical shifts were assessed using curve fitting, and mean absolute difference (MAD) between paired blood and sensor values were calculated. RESULTS - Curve fitting showed no significant differences between the two sensors. MAD +/- SD was 8.50 +/- 3.47% for the test sensor and 9.21 +/- 3.17% for the control sensor, P = 0.72. CONCLUSIONS - Microdialysis CGM can be accurately performed in the proximity of CSII systems",

author = "Jeroen Hermanides and Wentholt, {Iris M.} and Hart, {Augustinus A.} and Hoekstra, {Joost B.} and DeVries, {J. Hans}",

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doi = "https://doi.org/10.2337/dc08-0145",

language = "English",

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T1 - No apparent local effect of insulin on microdialysis continuous glucose-monitoring measurements

AU - Hermanides, Jeroen

AU - Wentholt, Iris M.

AU - Hart, Augustinus A.

AU - Hoekstra, Joost B.

AU - DeVries, J. Hans

PY - 2008

Y1 - 2008

N2 - OBJECTIVE - Data investigating the possible disturbing influence of insulin in the vicinity of continuous glucose monitoring (CGM) is lacking. We investigated the hypothesis that high local insulin concentrations would interfere with sensor readings. RESEARCH DESIGN AND METHODS - Two microdialysis sensors were inserted in the periumbilical region of 10 continuous subcutaneous insulin infusion (CSII)-treated type I patients. A test sensor was inserted as close as possible to the insulin catheter and compared with a control sensor. Glucose peak and nadir were induced. Horizontal and vertical shifts were assessed using curve fitting, and mean absolute difference (MAD) between paired blood and sensor values were calculated. RESULTS - Curve fitting showed no significant differences between the two sensors. MAD +/- SD was 8.50 +/- 3.47% for the test sensor and 9.21 +/- 3.17% for the control sensor, P = 0.72. CONCLUSIONS - Microdialysis CGM can be accurately performed in the proximity of CSII systems

AB - OBJECTIVE - Data investigating the possible disturbing influence of insulin in the vicinity of continuous glucose monitoring (CGM) is lacking. We investigated the hypothesis that high local insulin concentrations would interfere with sensor readings. RESEARCH DESIGN AND METHODS - Two microdialysis sensors were inserted in the periumbilical region of 10 continuous subcutaneous insulin infusion (CSII)-treated type I patients. A test sensor was inserted as close as possible to the insulin catheter and compared with a control sensor. Glucose peak and nadir were induced. Horizontal and vertical shifts were assessed using curve fitting, and mean absolute difference (MAD) between paired blood and sensor values were calculated. RESULTS - Curve fitting showed no significant differences between the two sensors. MAD +/- SD was 8.50 +/- 3.47% for the test sensor and 9.21 +/- 3.17% for the control sensor, P = 0.72. CONCLUSIONS - Microdialysis CGM can be accurately performed in the proximity of CSII systems

U2 - https://doi.org/10.2337/dc08-0145

DO - https://doi.org/10.2337/dc08-0145

M3 - Article

C2 - 18332157

SN - 0149-5992

VL - 31

SP - 1120

EP - 1122

JO - Diabetes Care

JF - Diabetes Care

IS - 6

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