TY - JOUR
T1 - No association between glucocorticoid diurnal rhythm in breastmilk and infant body composition at 3 months
AU - Hollanders, Jonneke
AU - Dijkstra, Lisette R.
AU - Van Der Voorn, Bibian
AU - Kouwenhoven, Stefanie M.P.
AU - Toorop, Alyssa A.
AU - Van Goudoever, Johannes B.
AU - Rotteveel, Joost
AU - Finken, Martijn J.J.
N1 - Funding Information: The study participants, for giving their time and energy to this study. D.L. for including mother-infant pairs and analyzing breastmilk and saliva samples. A.C.H., F.M., A.F. and other colleagues at the endocrinology laboratory for their contribution to the GC analyses. Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - Objective: Glucocorticoids (GCs) in breastmilk have previously been associated with infant body growth and body composition. However, the diurnal rhythm of breastmilk GCs was not taken into account, and we therefore aimed to assess the associations between breastmilk GC rhythmicity at 1 month and growth and body composition at 3 months in infants. Methods: At 1 month postpartum, breastmilk GCs were collected over a 24-h period and analyzed by LC-MS/MS. Body composition was measured using air-displacement plethysmography at 3 months. Length and weight were collected at 1, 2, and 3months. Results: In total, 42 healthymother–infant pairs were included. No associations were found between breastmilk GC rhythmicity (area-under-the-curve increase and ground,maximum, and delta) and infant growth trajectories or body composition (fat and fat freemass index, fat%) at 3months. Conclusions: This study did not find an association between breastmilk GC rhythmicity at 1 month and infant’s growth or body composition at 3 months. Therefore, this study suggests that previous observations linking breastmilk cortisol to changes in infant weight might be flawed by the lack of serial cortisol measurements and detailed information on body composition.
AB - Objective: Glucocorticoids (GCs) in breastmilk have previously been associated with infant body growth and body composition. However, the diurnal rhythm of breastmilk GCs was not taken into account, and we therefore aimed to assess the associations between breastmilk GC rhythmicity at 1 month and growth and body composition at 3 months in infants. Methods: At 1 month postpartum, breastmilk GCs were collected over a 24-h period and analyzed by LC-MS/MS. Body composition was measured using air-displacement plethysmography at 3 months. Length and weight were collected at 1, 2, and 3months. Results: In total, 42 healthymother–infant pairs were included. No associations were found between breastmilk GC rhythmicity (area-under-the-curve increase and ground,maximum, and delta) and infant growth trajectories or body composition (fat and fat freemass index, fat%) at 3months. Conclusions: This study did not find an association between breastmilk GC rhythmicity at 1 month and infant’s growth or body composition at 3 months. Therefore, this study suggests that previous observations linking breastmilk cortisol to changes in infant weight might be flawed by the lack of serial cortisol measurements and detailed information on body composition.
KW - Circadian rhythm
KW - Cortisol
KW - Cortisone
KW - Growth
KW - Human milk
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UR - https://www.ncbi.nlm.nih.gov/pubmed/31581748
U2 - https://doi.org/10.3390/nu11102351
DO - https://doi.org/10.3390/nu11102351
M3 - Article
C2 - 31581748
SN - 2072-6643
VL - 11
JO - NUTRIENTS
JF - NUTRIENTS
IS - 10
M1 - 2351
ER -