Abstract
While there is solid evidence that cannabis use is heritable, attempts to identify genetic influences at the molecular level have yielded mixed results. Here, a large twin family sample (n = 7452) was used to test for association between 10 previously reported candidate genes and lifetime frequency of cannabis use using a gene-based association test. None of the candidate genes reached even nominal significance (P < 0.05). The lack of replication may point to our limited understanding of the neurobiology of cannabis involvement and also to potential publication bias and false-positive findings in previous studies. © 2011 Society for the Study of Addiction.
Original language | English |
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Pages (from-to) | 687-690 |
Journal | Addiction Biology |
Volume | 17 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2012 |