Abstract
The present study was designed to investigate blood-brain permeability and the possible involvement of plasma proteins and blood-borne cells in amyloid plaque formation in scrapie-affected mice. No abnormal extravasation of intravenously injected horseradish peroxidase (HRP) was found and with immunocytochemical techniques no plasma proteins were detected in neuropil from scrapie-affected mice. In contrast to an earlier report, these findings suggest that the blood-brain barrier is essentially intact in scrapie-affected mice. Using immunohistochemical and enzyme histochemical methods no cells belonging to the monocyte-macrophage lineage were detected in association with amyloid plaques. Thus, by these methods there was no evidence that plasma proteins or blood-borne cells are involved in amyloid plaque formation in scrapie-affected mice. However, astrocytes were consistently found to be associated with amyloid plaques at all stages of their development.
Original language | English |
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Pages (from-to) | 251-256 |
Number of pages | 6 |
Journal | Virchows Archiv B Cell Pathology Including Molecular Pathology |
Volume | 53 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Dec 1987 |
Keywords
- Amyloid plaques
- Blood-brain barrier
- Macrophages
- Microglia
- Scrapie