No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine

M. van Vugt; F. Ezzet; F. Nosten; I. Gathmann; P. Wilairatana; S. Looareesuwan; N. J. White

No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine

M. van Vugt, F. Ezzet, F. Nosten, I. Gathmann, P. Wilairatana, S. Looareesuwan, N. J. White

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Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Artemether-lumefantrine is a new fixed antimalarial combination effective against multidrug-resistant falciparum malaria. A prospective electrocardiographic study was conducted in 150 patients receiving artemetherlumefantrine and 50 treated with artesunate-mefloquine. There was no evidence for clinically significant changes in the electrocardiographic intervals and in particular no relationship between plasma concentrations of lumefantrine and QTc prolongation. Artemether-lumefantrine does not have significant cardiac effects at therapeutic doses

Original language	English
Pages (from-to)	964-967
Journal	American journal of tropical medicine and hygiene
Volume	61
Issue number	6
Publication status	Published - 1999

Cite this

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title = "No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine",

abstract = "Artemether-lumefantrine is a new fixed antimalarial combination effective against multidrug-resistant falciparum malaria. A prospective electrocardiographic study was conducted in 150 patients receiving artemetherlumefantrine and 50 treated with artesunate-mefloquine. There was no evidence for clinically significant changes in the electrocardiographic intervals and in particular no relationship between plasma concentrations of lumefantrine and QTc prolongation. Artemether-lumefantrine does not have significant cardiac effects at therapeutic doses",

author = "{van Vugt}, M. and F. Ezzet and F. Nosten and I. Gathmann and P. Wilairatana and S. Looareesuwan and White, {N. J.}",

year = "1999",

language = "English",

volume = "61",

pages = "964--967",

journal = "American journal of tropical medicine and hygiene",

issn = "0002-9637",

publisher = "American Society of Tropical Medicine and Hygiene",

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TY - JOUR

T1 - No evidence of cardiotoxicity during antimalarial treatment with artemether-lumefantrine

AU - van Vugt, M.

AU - Ezzet, F.

AU - Nosten, F.

AU - Gathmann, I.

AU - Wilairatana, P.

AU - Looareesuwan, S.

AU - White, N. J.

PY - 1999

Y1 - 1999

N2 - Artemether-lumefantrine is a new fixed antimalarial combination effective against multidrug-resistant falciparum malaria. A prospective electrocardiographic study was conducted in 150 patients receiving artemetherlumefantrine and 50 treated with artesunate-mefloquine. There was no evidence for clinically significant changes in the electrocardiographic intervals and in particular no relationship between plasma concentrations of lumefantrine and QTc prolongation. Artemether-lumefantrine does not have significant cardiac effects at therapeutic doses

AB - Artemether-lumefantrine is a new fixed antimalarial combination effective against multidrug-resistant falciparum malaria. A prospective electrocardiographic study was conducted in 150 patients receiving artemetherlumefantrine and 50 treated with artesunate-mefloquine. There was no evidence for clinically significant changes in the electrocardiographic intervals and in particular no relationship between plasma concentrations of lumefantrine and QTc prolongation. Artemether-lumefantrine does not have significant cardiac effects at therapeutic doses

M3 - Article

C2 - 10674679

SN - 0002-9637

VL - 61

SP - 964

EP - 967

JO - American journal of tropical medicine and hygiene

JF - American journal of tropical medicine and hygiene

IS - 6

ER -