No evidence of microbleeds in ALS patients at 7 Tesla MRI

Esther Verstraete; Geert Jan Biessels; Martijn P. Van Den Heuvel; Fredy Visser; Peter R. Luijten; Leonard H. Van Den Berg

doi:https://doi.org/10.3109/17482968.2010.513053

No evidence of microbleeds in ALS patients at 7 Tesla MRI

Esther Verstraete, Geert Jan Biessels, Martijn P. Van Den Heuvel, Fredy Visser, Peter R. Luijten, Leonard H. Van Den Berg

Human Genetics (VUmc)

Research output: Contribution to journal › Article › Academic › peer-review

22 Citations (Scopus)

Abstract

There have been several reports about disruption of the blood-spinal cord barrier (BSCB) and blood-brain barrier (BBB) in SOD1 mutant mice. Pathologically, microbleeds and hemosiderine deposits were found. We investigated patients with ALS for the occurrence of cerebral microbleeds with 7 Tesla MRI. Twelve patients with ALS and 12 age- and sex-matched healthy controls were studied. We performed T2*-weighed imaging which enables whole-brain in vivo detection of cerebral microbleeds and hemosiderin deposits in humans. No microbleeds were found in patients with ALS.

Original language	English
Pages (from-to)	555-557
Number of pages	3
Journal	Amyotrophic lateral sclerosis
Volume	11
Issue number	6
DOIs	https://doi.org/10.3109/17482968.2010.513053
Publication status	Published - 1 Dec 2010

Keywords

Amyotrophic lateral sclerosis
Blood-brain barrier
Microbleeds
Motor neuron disease

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title = "No evidence of microbleeds in ALS patients at 7 Tesla MRI",

abstract = "There have been several reports about disruption of the blood-spinal cord barrier (BSCB) and blood-brain barrier (BBB) in SOD1 mutant mice. Pathologically, microbleeds and hemosiderine deposits were found. We investigated patients with ALS for the occurrence of cerebral microbleeds with 7 Tesla MRI. Twelve patients with ALS and 12 age- and sex-matched healthy controls were studied. We performed T2*-weighed imaging which enables whole-brain in vivo detection of cerebral microbleeds and hemosiderin deposits in humans. No microbleeds were found in patients with ALS.",

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AU - Biessels, Geert Jan

AU - Van Den Heuvel, Martijn P.

AU - Visser, Fredy

AU - Luijten, Peter R.

AU - Van Den Berg, Leonard H.

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No evidence of microbleeds in ALS patients at 7 Tesla MRI

Abstract

Keywords

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