No evidence of microbleeds in ALS patients at 7 Tesla MRI

Esther Verstraete, Geert Jan Biessels, Martijn P. Van Den Heuvel, Fredy Visser, Peter R. Luijten, Leonard H. Van Den Berg

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22 Citations (Scopus)


There have been several reports about disruption of the blood-spinal cord barrier (BSCB) and blood-brain barrier (BBB) in SOD1 mutant mice. Pathologically, microbleeds and hemosiderine deposits were found. We investigated patients with ALS for the occurrence of cerebral microbleeds with 7 Tesla MRI. Twelve patients with ALS and 12 age- and sex-matched healthy controls were studied. We performed T2*-weighed imaging which enables whole-brain in vivo detection of cerebral microbleeds and hemosiderin deposits in humans. No microbleeds were found in patients with ALS.

Original languageEnglish
Pages (from-to)555-557
Number of pages3
JournalAmyotrophic lateral sclerosis
Issue number6
Publication statusPublished - 1 Dec 2010


  • Amyotrophic lateral sclerosis
  • Blood-brain barrier
  • Microbleeds
  • Motor neuron disease

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