No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda

Arthur W. D. Edridge; Nathalie van den Brekel; Philly Mukungu; Rachael Nakayima; Samuel Bbosa; Peter Isagara; Michael Boele van Hensbroek; Lia van der Hoek; John Kayiwa; Julius J. Lutwama; Richard Idro

doi:https://doi.org/10.3390/tropicalmed8010021

No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda

Arthur W. D. Edridge, Nathalie van den Brekel, Philly Mukungu, Rachael Nakayima, Samuel Bbosa, Peter Isagara, Michael Boele van Hensbroek, Lia van der Hoek, John Kayiwa, Julius J. Lutwama, Richard Idro

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

We investigated whether Ntwetwe virus?a novel orthobunyavirus discovered in a Ugandan girl with a fatal encephalopathy?was a common reason for hospital admission for children to Kiboga hospital, Uganda. A case?control was conducted between September 2019 and September 2020, including cases with severe neurological disease and mild febrile illness, matched to a healthy control without fever. Among 143 subjects, no cases with an acute infection were identified. This result suggests that Ntwetwe virus does not cause a major burden of disease amongst children presenting to Kiboga hospital during the study period.

Original language	English
Article number	21
Journal	Tropical Medicine and Infectious Disease
Volume	8
Issue number	1
DOIs	https://doi.org/10.3390/tropicalmed8010021
Publication status	Published - 1 Jan 2023

Keywords

CNS infection
Uganda
emerging infectious diseases
orthobunyavirus
pediatrics
virus discovery

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Edridge, A. W. D., van den Brekel, N., Mukungu, P., Nakayima, R., Bbosa, S., Isagara, P., Boele van Hensbroek, M., van der Hoek, L., Kayiwa, J., Lutwama, J. J., & Idro, R. (2023). No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda. Tropical Medicine and Infectious Disease, 8(1), Article 21. https://doi.org/10.3390/tropicalmed8010021

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title = "No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda",

abstract = "We investigated whether Ntwetwe virus?a novel orthobunyavirus discovered in a Ugandan girl with a fatal encephalopathy?was a common reason for hospital admission for children to Kiboga hospital, Uganda. A case?control was conducted between September 2019 and September 2020, including cases with severe neurological disease and mild febrile illness, matched to a healthy control without fever. Among 143 subjects, no cases with an acute infection were identified. This result suggests that Ntwetwe virus does not cause a major burden of disease amongst children presenting to Kiboga hospital during the study period.",

keywords = "CNS infection, Uganda, emerging infectious diseases, orthobunyavirus, pediatrics, virus discovery",

author = "Edridge, {Arthur W. D.} and {van den Brekel}, Nathalie and Philly Mukungu and Rachael Nakayima and Samuel Bbosa and Peter Isagara and {Boele van Hensbroek}, Michael and {van der Hoek}, Lia and John Kayiwa and Lutwama, {Julius J.} and Richard Idro",

note = "Funding Information: This work was supported by an ESCMID Research Grant (to A.W.D.E), a grant from the Schumacher Kramer Foundation and a grant from PrimaGen Holding. Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2023",

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doi = "https://doi.org/10.3390/tropicalmed8010021",

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AU - Edridge, Arthur W. D.

AU - van den Brekel, Nathalie

AU - Mukungu, Philly

AU - Nakayima, Rachael

AU - Bbosa, Samuel

AU - Isagara, Peter

AU - Boele van Hensbroek, Michael

AU - van der Hoek, Lia

AU - Kayiwa, John

AU - Lutwama, Julius J.

AU - Idro, Richard

N1 - Funding Information: This work was supported by an ESCMID Research Grant (to A.W.D.E), a grant from the Schumacher Kramer Foundation and a grant from PrimaGen Holding. Publisher Copyright: © 2022 by the authors.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - We investigated whether Ntwetwe virus?a novel orthobunyavirus discovered in a Ugandan girl with a fatal encephalopathy?was a common reason for hospital admission for children to Kiboga hospital, Uganda. A case?control was conducted between September 2019 and September 2020, including cases with severe neurological disease and mild febrile illness, matched to a healthy control without fever. Among 143 subjects, no cases with an acute infection were identified. This result suggests that Ntwetwe virus does not cause a major burden of disease amongst children presenting to Kiboga hospital during the study period.

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KW - CNS infection

KW - Uganda

KW - emerging infectious diseases

KW - orthobunyavirus

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JF - Tropical Medicine and Infectious Disease

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ER -

No Evidence of Ntwetwe Virus Infections in Children Presenting to Kiboga Hospital, Uganda

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Keywords

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