Non-contact spectroscopic determination of large blood volume fractions in turbid media

Rolf H. Bremmer; Stephen C. Kanick; Nick Laan; Arjen Amelink; Ton G. van Leeuwen; Maurice C. G. Aalders

doi:https://doi.org/10.1364/BOE.2.000396

Non-contact spectroscopic determination of large blood volume fractions in turbid media

Rolf H. Bremmer, Stephen C. Kanick, Nick Laan, Arjen Amelink, Ton G. van Leeuwen, Maurice C. G. Aalders

Research output: Contribution to journal › Article › Academic › peer-review

9 Citations (Scopus)

Abstract

We report on a non-contact method to quantitatively determine blood volume fractions in turbid media by reflectance spectroscopy in the VIS/NIR spectral wavelength range. This method will be used for spectral analysis of tissue with large absorption coefficients and assist in age determination of bruises and bloodstains. First, a phantom set was constructed to determine the effective photon path length as a function of μ(a) and μ(s)' on phantoms with an albedo range: 0.02-0.99. Based on these measurements, an empirical model of the path length was established for phantoms with an albedo > 0.1. Next, this model was validated on whole blood mimicking phantoms, to determine the blood volume fractions ρ = 0.12-0.84 within the phantoms (r = 0.993; error < 10%). Finally, the model was proved applicable on cotton fabric phantoms

Original language	English
Pages (from-to)	396-407
Journal	Biomedical Optics Express
Volume	2
Issue number	2
DOIs	https://doi.org/10.1364/BOE.2.000396
Publication status	Published - 2011

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https://doi.org/10.1364/BOE.2.000396

Cite this

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title = "Non-contact spectroscopic determination of large blood volume fractions in turbid media",

abstract = "We report on a non-contact method to quantitatively determine blood volume fractions in turbid media by reflectance spectroscopy in the VIS/NIR spectral wavelength range. This method will be used for spectral analysis of tissue with large absorption coefficients and assist in age determination of bruises and bloodstains. First, a phantom set was constructed to determine the effective photon path length as a function of μ(a) and μ(s)' on phantoms with an albedo range: 0.02-0.99. Based on these measurements, an empirical model of the path length was established for phantoms with an albedo > 0.1. Next, this model was validated on whole blood mimicking phantoms, to determine the blood volume fractions ρ = 0.12-0.84 within the phantoms (r = 0.993; error < 10%). Finally, the model was proved applicable on cotton fabric phantoms",

author = "Bremmer, {Rolf H.} and Kanick, {Stephen C.} and Nick Laan and Arjen Amelink and {van Leeuwen}, {Ton G.} and Aalders, {Maurice C. G.}",

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doi = "https://doi.org/10.1364/BOE.2.000396",

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T1 - Non-contact spectroscopic determination of large blood volume fractions in turbid media

AU - Bremmer, Rolf H.

AU - Kanick, Stephen C.

AU - Laan, Nick

AU - Amelink, Arjen

AU - van Leeuwen, Ton G.

AU - Aalders, Maurice C. G.

PY - 2011

Y1 - 2011

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AB - We report on a non-contact method to quantitatively determine blood volume fractions in turbid media by reflectance spectroscopy in the VIS/NIR spectral wavelength range. This method will be used for spectral analysis of tissue with large absorption coefficients and assist in age determination of bruises and bloodstains. First, a phantom set was constructed to determine the effective photon path length as a function of μ(a) and μ(s)' on phantoms with an albedo range: 0.02-0.99. Based on these measurements, an empirical model of the path length was established for phantoms with an albedo > 0.1. Next, this model was validated on whole blood mimicking phantoms, to determine the blood volume fractions ρ = 0.12-0.84 within the phantoms (r = 0.993; error < 10%). Finally, the model was proved applicable on cotton fabric phantoms

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DO - https://doi.org/10.1364/BOE.2.000396

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