Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors

I. Shemer; C. Holmgren; R. Min; L. Fülöp; M. Zilberter; K.M. Sousa; T. Farkas; W. Härtig; B. Penke; N. Burnashev; H. Tanila; Z. Zilberter; T. Harkany; Yuri Zilberter

doi:https://doi.org/10.1111/j.1460-9568.2006.04733.x

Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors

I. Shemer, C. Holmgren, R. Min, L. Fülöp, M. Zilberter, K.M. Sousa, T. Farkas, W. Härtig, B. Penke, N. Burnashev, H. Tanila, Z. Zilberter, T. Harkany, Yuri Zilberter

Research output: Contribution to journal › Article › Academic › peer-review

75 Citations (Scopus)

Abstract

Cognitive decline in Alzheimer's disease (AD) stems from the progressive dysfunction of synaptic connections within cortical neuronal microcircuits. Recently, soluble amyloid β protein oligomers (Aβ

Original language	English
Pages (from-to)	2035-2047
Number of pages	13
Journal	European Journal of Neuroscience
Volume	23
Issue number	8
DOIs	https://doi.org/10.1111/j.1460-9568.2006.04733.x
Publication status	Published - Apr 2006

Keywords

Action Potentials/drug effects
Age Factors
Alzheimer Disease
Amyloid beta-Peptides/chemistry
Amyloid beta-Protein Precursor/genetics
Animals
Animals, Newborn
Disease Models, Animal
Electric Stimulation/methods
Excitatory Amino Acid Agonists/pharmacology
Excitatory Postsynaptic Potentials/drug effects
Gene Expression
Immunohistochemistry/methods
Male
Mice
Mice, Transgenic
N-Methylaspartate/pharmacology
Neocortex/pathology
Patch-Clamp Techniques/methods
Pyramidal Cells/drug effects
RNA, Messenger/metabolism
Receptors, AMPA/classification
Reverse Transcriptase Polymerase Chain Reaction/methods
Synapses/drug effects
Time Factors
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

https://doi.org/10.1111/j.1460-9568.2006.04733.x

Cite this

Shemer, I., Holmgren, C., Min, R., Fülöp, L., Zilberter, M., Sousa, K. M., Farkas, T., Härtig, W., Penke, B., Burnashev, N., Tanila, H., Zilberter, Z., Harkany, T., & Zilberter, Y. (2006). Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors. European Journal of Neuroscience, 23(8), 2035-2047. https://doi.org/10.1111/j.1460-9568.2006.04733.x

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title = "Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors",

abstract = "Cognitive decline in Alzheimer's disease (AD) stems from the progressive dysfunction of synaptic connections within cortical neuronal microcircuits. Recently, soluble amyloid β protein oligomers (Aβ",

keywords = "Action Potentials/drug effects, Age Factors, Alzheimer Disease, Amyloid beta-Peptides/chemistry, Amyloid beta-Protein Precursor/genetics, Animals, Animals, Newborn, Disease Models, Animal, Electric Stimulation/methods, Excitatory Amino Acid Agonists/pharmacology, Excitatory Postsynaptic Potentials/drug effects, Gene Expression, Immunohistochemistry/methods, Male, Mice, Mice, Transgenic, N-Methylaspartate/pharmacology, Neocortex/pathology, Patch-Clamp Techniques/methods, Pyramidal Cells/drug effects, RNA, Messenger/metabolism, Receptors, AMPA/classification, Reverse Transcriptase Polymerase Chain Reaction/methods, Synapses/drug effects, Time Factors, alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology",

author = "I. Shemer and C. Holmgren and R. Min and L. F{\"u}l{\"o}p and M. Zilberter and K.M. Sousa and T. Farkas and W. H{\"a}rtig and B. Penke and N. Burnashev and H. Tanila and Z. Zilberter and T. Harkany and Yuri Zilberter",

year = "2006",

month = apr,

doi = "https://doi.org/10.1111/j.1460-9568.2006.04733.x",

language = "English",

volume = "23",

pages = "2035--2047",

journal = "European Journal of Neuroscience",

issn = "0953-816X",

publisher = "Wiley-Blackwell",

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}

Shemer, I, Holmgren, C, Min, R, Fülöp, L, Zilberter, M, Sousa, KM, Farkas, T, Härtig, W, Penke, B, Burnashev, N, Tanila, H, Zilberter, Z, Harkany, T & Zilberter, Y 2006, 'Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors', European Journal of Neuroscience, vol. 23, no. 8, pp. 2035-2047. https://doi.org/10.1111/j.1460-9568.2006.04733.x

Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors. / Shemer, I.; Holmgren, C.; Min, R. et al.
In: European Journal of Neuroscience, Vol. 23, No. 8, 04.2006, p. 2035-2047.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Non-fibrillar beta-amyloid abates spike-timing-dependent synaptic potentiation at excitatory synapses in layer 2/3 of the neocortex by targeting postsynaptic AMPA receptors

AU - Shemer, I.

AU - Holmgren, C.

AU - Min, R.

AU - Fülöp, L.

AU - Zilberter, M.

AU - Sousa, K.M.

AU - Farkas, T.

AU - Härtig, W.

AU - Penke, B.

AU - Burnashev, N.

AU - Tanila, H.

AU - Zilberter, Z.

AU - Harkany, T.

AU - Zilberter, Yuri

PY - 2006/4

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KW - Action Potentials/drug effects

KW - Age Factors

KW - Alzheimer Disease

KW - Amyloid beta-Peptides/chemistry

KW - Amyloid beta-Protein Precursor/genetics

KW - Animals

KW - Animals, Newborn

KW - Disease Models, Animal

KW - Electric Stimulation/methods

KW - Excitatory Amino Acid Agonists/pharmacology

KW - Excitatory Postsynaptic Potentials/drug effects

KW - Gene Expression

KW - Immunohistochemistry/methods

KW - Male

KW - Mice

KW - Mice, Transgenic

KW - N-Methylaspartate/pharmacology

KW - Neocortex/pathology

KW - Patch-Clamp Techniques/methods

KW - Pyramidal Cells/drug effects

KW - RNA, Messenger/metabolism

KW - Receptors, AMPA/classification

KW - Reverse Transcriptase Polymerase Chain Reaction/methods

KW - Synapses/drug effects

KW - Time Factors

KW - alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/pharmacology

U2 - https://doi.org/10.1111/j.1460-9568.2006.04733.x

DO - https://doi.org/10.1111/j.1460-9568.2006.04733.x

M3 - Article

C2 - 16630051

SN - 0953-816X

VL - 23

SP - 2035

EP - 2047

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

IS - 8

ER -