Non-human primate models of multiple sclerosis

H P Brok, J Bauer, M Jonker, E Blezer, S Amor, R E Bontrop, J D Laman, B A 't Hart

Research output: Contribution to journalReview articleAcademicpeer-review

83 Citations (Scopus)


The phylogenetic proximity between non-human primate species and humans is reflected by a high degree of immunological similarity. Non-human primates therefore provide important experimental models for disorders in the human population that are caused by the immune system, such as autoimmune diseases. In this paper we describe non-human primate models of multiple sclerosis, a chronic inflammatory and demyelinating disease of the human central nervous system. While reviewing data from the literature and our own research we will discuss the unique role of such models in the research of basic disease mechanisms and the development of new therapies.

Original languageEnglish
Pages (from-to)173-85
Number of pages13
JournalImmunological reviews
Publication statusPublished - Oct 2001


  • Animals
  • Brain
  • Callithrix
  • Disease Models, Animal
  • Encephalomyelitis, Autoimmune, Experimental
  • Female
  • Glycoproteins
  • Journal Article
  • Macaca
  • Male
  • Multiple Sclerosis
  • Myelin-Oligodendrocyte Glycoprotein
  • Peptide Fragments
  • Review

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