TY - JOUR
T1 - Non-invasive antenatal RHD typing
AU - van der Schoot, C. E.
AU - Soussan, A. Ait
AU - Koelewijn, J.
AU - Bonsel, G.
AU - Paget-Christiaens, L. G. C.
AU - de Haas, M.
PY - 2006
Y1 - 2006
N2 - The existence of cell free fetal DNA, derived from apoptotic syncytiotrophoblast, in the maternal circulation has opened new possibilities of non-invasive prenatal diagnosis. Although still some technical problems exists, especially the lack of a generic positive control on the presence of fetal DNA and the aspecific amplification of background maternal DNA, non-invasive prenatal RHD typing has been successfully introduced in several laboratories, especially in Europe. The diagnostic accuracy reaches>99%. In the Netherlands PCR guided administration of antenatal anti-D prophylaxis is cost-effective and nearby. In this review the main characteristics and applications of cell free fetal DNA are discussed, with an emphasis on prenatal RHD genotyping
AB - The existence of cell free fetal DNA, derived from apoptotic syncytiotrophoblast, in the maternal circulation has opened new possibilities of non-invasive prenatal diagnosis. Although still some technical problems exists, especially the lack of a generic positive control on the presence of fetal DNA and the aspecific amplification of background maternal DNA, non-invasive prenatal RHD typing has been successfully introduced in several laboratories, especially in Europe. The diagnostic accuracy reaches>99%. In the Netherlands PCR guided administration of antenatal anti-D prophylaxis is cost-effective and nearby. In this review the main characteristics and applications of cell free fetal DNA are discussed, with an emphasis on prenatal RHD genotyping
U2 - https://doi.org/10.1016/j.tracli.2006.02.021
DO - https://doi.org/10.1016/j.tracli.2006.02.021
M3 - Article
C2 - 16564727
SN - 1246-7820
VL - 13
SP - 53
EP - 57
JO - Transfusion clinique et biologique
JF - Transfusion clinique et biologique
IS - 1-2
ER -