Abstract
The T(H)1 vs non-T(H)1 cytokine balance in Guillain-Barré syndrome (GBS) is unknown. Using enzyme-linked immunospot (ELISPOT) assays, we observed elevated numbers of interleukin (IL)-6 and IL-10-secreting blood mononuclear cells (BMNC) during the acute phase in untreated patients, and low levels of tumor necrosis factor alpha-secreting BMNC in the recovery phase of GBS. Numbers of IL-12p70-secreting BMNC were not affected over the course of GBS. The non-T(H)1 cytokine profile observed early in GBS may explain the self-limited clinical course associated with GBS.
| Original language | English |
|---|---|
| Pages (from-to) | 476-8 |
| Number of pages | 3 |
| Journal | Neurology |
| Volume | 58 |
| Issue number | 3 |
| Publication status | Published - 12 Feb 2002 |
Keywords
- Acute Disease
- Guillain-Barre Syndrome/immunology
- Humans
- Interleukin-10/metabolism
- Interleukin-12/metabolism
- Interleukin-6/metabolism
- Leukocytes, Mononuclear/immunology
- Th1 Cells/immunology
- Tumor Necrosis Factor-alpha/metabolism