Non-T(H)1 cytokines are augmented systematically early in Guillain-Barré syndrome

Rayomand Press, V Ozenci, M Kouwenhoven, H Link

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The T(H)1 vs non-T(H)1 cytokine balance in Guillain-Barré syndrome (GBS) is unknown. Using enzyme-linked immunospot (ELISPOT) assays, we observed elevated numbers of interleukin (IL)-6 and IL-10-secreting blood mononuclear cells (BMNC) during the acute phase in untreated patients, and low levels of tumor necrosis factor alpha-secreting BMNC in the recovery phase of GBS. Numbers of IL-12p70-secreting BMNC were not affected over the course of GBS. The non-T(H)1 cytokine profile observed early in GBS may explain the self-limited clinical course associated with GBS.

Original languageEnglish
Pages (from-to)476-8
Number of pages3
Issue number3
Publication statusPublished - 12 Feb 2002


  • Acute Disease
  • Guillain-Barre Syndrome/immunology
  • Humans
  • Interleukin-10/metabolism
  • Interleukin-12/metabolism
  • Interleukin-6/metabolism
  • Leukocytes, Mononuclear/immunology
  • Th1 Cells/immunology
  • Tumor Necrosis Factor-alpha/metabolism

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