TY - JOUR
T1 - Noncanonical NF-kappa B signaling in dendritic cells is required for indoleamine 2,3-dioxygenase (IDO) induction and immune regulation
AU - Tas, Sander W.
AU - Vervoordeldonk, Margriet J.
AU - Hajji, Najat
AU - Schuitemaker, Joost H. N.
AU - van der Sluijs, Koen F.
AU - May, Michael J.
AU - Ghosh, Sankar
AU - Kapsenberg, Martien L.
AU - Tak, Paul P.
AU - de Jong, Esther C.
PY - 2007
Y1 - 2007
N2 - Ligation of CD40 on dendritic cells (DCs) induces early production of inflammatory mediators via canonical NF-kappa B signaling, as well as late expression of the anti inflammatory enzyme indoleamine 2,3dioxygenase (IDO) via unknown signal transduction. By selective blocking of either the canonical NF-kappa B pathway using the NEMO-binding domain peptide or the noncanonical NF-kappa B pathway by small interfering RNA, we demonstrate that IDO expression requires noncanonical NF-kappa B signaling. Also, noncanonical NF-kappa B signaling down-regulates proinflammatory cytokine production in DCs. In addition, selective activation of the noncanonical NF-kappa B pathway results in noninflammatory DCs that suppress T-cell activation and promote the development of T cells with regulatory properties. These findings reveal an important role of the noncanonical NF-kappa B pathway in the regulation of immunity
AB - Ligation of CD40 on dendritic cells (DCs) induces early production of inflammatory mediators via canonical NF-kappa B signaling, as well as late expression of the anti inflammatory enzyme indoleamine 2,3dioxygenase (IDO) via unknown signal transduction. By selective blocking of either the canonical NF-kappa B pathway using the NEMO-binding domain peptide or the noncanonical NF-kappa B pathway by small interfering RNA, we demonstrate that IDO expression requires noncanonical NF-kappa B signaling. Also, noncanonical NF-kappa B signaling down-regulates proinflammatory cytokine production in DCs. In addition, selective activation of the noncanonical NF-kappa B pathway results in noninflammatory DCs that suppress T-cell activation and promote the development of T cells with regulatory properties. These findings reveal an important role of the noncanonical NF-kappa B pathway in the regulation of immunity
U2 - https://doi.org/10.1182/blood-2006-11-056010
DO - https://doi.org/10.1182/blood-2006-11-056010
M3 - Article
C2 - 17483297
SN - 0006-4971
VL - 110
SP - 1540
EP - 1549
JO - Blood
JF - Blood
IS - 5
ER -