TY - JOUR
T1 - Noncoding RNAs emerging as novel biomarkers in pancreatic cancer
AU - Garajová, Ingrid
AU - Balsano, Rita
AU - Tommasi, Chiara
AU - Giovannetti, Elisa
PY - 2018
Y1 - 2018
N2 - Noncoding RNAs play important regulatory roles in diverse biological processes and their misregula-tion might lead to different diseases, including cancer. Previous studies have reported the evolving role of miR-NAs as new potential biomarkers in cancer diagnosis, prognosis, as well as predictive biomarkers of chemotherapy response or therapeutic targets. In this review, we outline the involvement of noncoding RNA in pancreatic cancer, providing an overview of known miRNAs in its diagnosis, prognosis and chemoresistance. In addition, we discuss the influence of non-coding RNAs in the metastatic behavior of pancreatic cancer, as well as the role of diet in epigenetic regulation of non-coding RNAs in cancer, which can, in turn, lead the development of new prevention’s techniques or novel targets for cancer therapy.
AB - Noncoding RNAs play important regulatory roles in diverse biological processes and their misregula-tion might lead to different diseases, including cancer. Previous studies have reported the evolving role of miR-NAs as new potential biomarkers in cancer diagnosis, prognosis, as well as predictive biomarkers of chemotherapy response or therapeutic targets. In this review, we outline the involvement of noncoding RNA in pancreatic cancer, providing an overview of known miRNAs in its diagnosis, prognosis and chemoresistance. In addition, we discuss the influence of non-coding RNAs in the metastatic behavior of pancreatic cancer, as well as the role of diet in epigenetic regulation of non-coding RNAs in cancer, which can, in turn, lead the development of new prevention’s techniques or novel targets for cancer therapy.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85063965985&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30659532
U2 - https://doi.org/10.2174/1381612825666190119125804
DO - https://doi.org/10.2174/1381612825666190119125804
M3 - Review article
C2 - 30659532
SN - 1381-6128
VL - 24
SP - 4601
EP - 4604
JO - Current pharmaceutical design
JF - Current pharmaceutical design
IS - 39
ER -