Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension .

C.T. Gan; J.W. Lankhaar; N. Westerhof; J.T. Marcus; A. Becker; J.W.R. Twisk; A. Boonstra; P.E. Postmus; A. Vonk Noordegraaf

doi:https://doi.org/10.1378/chest.07-1246

Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension .

C.T. Gan, J.W. Lankhaar, N. Westerhof, J.T. Marcus, A. Becker, J.W.R. Twisk, A. Boonstra, P.E. Postmus, A. Vonk Noordegraaf

Research output: Contribution to journal › Article › Academic › peer-review

327 Citations (Scopus)

Abstract

Aims: Decreased total compliance of the pulmonary vascular bed is associated with increased mortality in patients with pulmonary arterial hypertension (PAH). We investigated whether proximal pulmonary artery stiffness, in terms of area distensibility and noninvasively assessed relative area change (RAC), calculated as relative cross-sectional area change, predicts mortality in patients with PAH. Methods and results: Eighty-six subjects underwent right-heart catheterization and MRI to assess area distensibility and RAC. Patients were followed up to 48 months. Kaplan-Meier plot and Cox proportional hazards regression analyses assessed the predictive value of area distensibility and RAC. In 70 patients, the diagnosis PAH was confirmed, and 16 subjects served as control subjects. In comparison with control subjects, proximal pulmonary arteries of patients were distended (685 ± 214 mm

Original language	English
Pages (from-to)	1906-1912
Number of pages	7
Journal	Chest
Volume	132
Issue number	6
DOIs	https://doi.org/10.1378/chest.07-1246
Publication status	Published - Dec 2007

Keywords

Adult
Cardiac Catheterization
Case-Control Studies
Elasticity
Female
Humans
Hypertension, Pulmonary/mortality
Least-Squares Analysis
Magnetic Resonance Imaging
Male
Middle Aged
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Pulmonary Artery/physiopathology

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Access to Document

https://doi.org/10.1378/chest.07-1246

Cite this

@article{16834656383747168a162af5ebd63811,

title = "Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension .",

abstract = "Aims: Decreased total compliance of the pulmonary vascular bed is associated with increased mortality in patients with pulmonary arterial hypertension (PAH). We investigated whether proximal pulmonary artery stiffness, in terms of area distensibility and noninvasively assessed relative area change (RAC), calculated as relative cross-sectional area change, predicts mortality in patients with PAH. Methods and results: Eighty-six subjects underwent right-heart catheterization and MRI to assess area distensibility and RAC. Patients were followed up to 48 months. Kaplan-Meier plot and Cox proportional hazards regression analyses assessed the predictive value of area distensibility and RAC. In 70 patients, the diagnosis PAH was confirmed, and 16 subjects served as control subjects. In comparison with control subjects, proximal pulmonary arteries of patients were distended (685 ± 214 mm",

keywords = "Adult, Cardiac Catheterization, Case-Control Studies, Elasticity, Female, Humans, Hypertension, Pulmonary/mortality, Least-Squares Analysis, Magnetic Resonance Imaging, Male, Middle Aged, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Pulmonary Artery/physiopathology",

author = "C.T. Gan and J.W. Lankhaar and N. Westerhof and J.T. Marcus and A. Becker and J.W.R. Twisk and A. Boonstra and P.E. Postmus and {Vonk Noordegraaf}, A.",

note = "Dec.",

year = "2007",

month = dec,

doi = "https://doi.org/10.1378/chest.07-1246",

language = "English",

volume = "132",

pages = "1906--1912",

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TY - JOUR

T1 - Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension .

AU - Gan, C.T.

AU - Lankhaar, J.W.

AU - Westerhof, N.

AU - Marcus, J.T.

AU - Becker, A.

AU - Twisk, J.W.R.

AU - Boonstra, A.

AU - Postmus, P.E.

AU - Vonk Noordegraaf, A.

N1 - Dec.

PY - 2007/12

Y1 - 2007/12

N2 - Aims: Decreased total compliance of the pulmonary vascular bed is associated with increased mortality in patients with pulmonary arterial hypertension (PAH). We investigated whether proximal pulmonary artery stiffness, in terms of area distensibility and noninvasively assessed relative area change (RAC), calculated as relative cross-sectional area change, predicts mortality in patients with PAH. Methods and results: Eighty-six subjects underwent right-heart catheterization and MRI to assess area distensibility and RAC. Patients were followed up to 48 months. Kaplan-Meier plot and Cox proportional hazards regression analyses assessed the predictive value of area distensibility and RAC. In 70 patients, the diagnosis PAH was confirmed, and 16 subjects served as control subjects. In comparison with control subjects, proximal pulmonary arteries of patients were distended (685 ± 214 mm

AB - Aims: Decreased total compliance of the pulmonary vascular bed is associated with increased mortality in patients with pulmonary arterial hypertension (PAH). We investigated whether proximal pulmonary artery stiffness, in terms of area distensibility and noninvasively assessed relative area change (RAC), calculated as relative cross-sectional area change, predicts mortality in patients with PAH. Methods and results: Eighty-six subjects underwent right-heart catheterization and MRI to assess area distensibility and RAC. Patients were followed up to 48 months. Kaplan-Meier plot and Cox proportional hazards regression analyses assessed the predictive value of area distensibility and RAC. In 70 patients, the diagnosis PAH was confirmed, and 16 subjects served as control subjects. In comparison with control subjects, proximal pulmonary arteries of patients were distended (685 ± 214 mm

KW - Adult

KW - Cardiac Catheterization

KW - Case-Control Studies

KW - Elasticity

KW - Female

KW - Humans

KW - Hypertension, Pulmonary/mortality

KW - Least-Squares Analysis

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Predictive Value of Tests

KW - Prognosis

KW - Proportional Hazards Models

KW - Pulmonary Artery/physiopathology

U2 - https://doi.org/10.1378/chest.07-1246

DO - https://doi.org/10.1378/chest.07-1246

M3 - Article

C2 - 17989161

SN - 0012-3692

VL - 132

SP - 1906

EP - 1912

JO - Chest

JF - Chest

IS - 6

ER -