Normal and abnormal development of the heart

Robert H. Anderson; Antoon F.M. Moorman; Nigel A. Brown; Simon D. Bamforth; Bill Chaudhry; Deborah J. Henderson; Timothy J. Mohun

doi:https://doi.org/10.1007/978-1-4471-4619-3_153

Normal and abnormal development of the heart

Robert H. Anderson, Antoon F.M. Moorman, Nigel A. Brown, Simon D. Bamforth, Bill Chaudhry, Deborah J. Henderson, Timothy J. Mohun

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic › peer-review

6 Citations (Scopus)

Abstract

Accurate knowledge of embryology is essential for interpretation of congenital cardiac malformations. Recent advances made in the understanding of cardiac development now make it possible to appreciate the morphology of not only the normal heart but also many congenital cardiac malformations. This is true not only for the molecular mechanisms that might lead to the malformations but also for the structure of the normal and abnormally developing heart. In this chapter, we discuss the progress made in demonstrating the structure of the developing heart, along with knowledge of the changes that occur in the expression of the genes and their products, which control the formation and differentiation of its various components.

Original language	English
Title of host publication	Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care
Publisher	Springer-Verlag London Ltd
Pages	151-177
Number of pages	27
ISBN (Electronic)	9781447146193
ISBN (Print)	9781447146186
DOIs	https://doi.org/10.1007/978-1-4471-4619-3_153
Publication status	Published - 1 Jan 2014

Keywords

Atrioventricular cushions
Cardiac conduction system
Coronary circulation
Endocardial cushions
Heart tube
Outflow tracts
Sinus venosus

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https://doi.org/10.1007/978-1-4471-4619-3_153

Cite this

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abstract = "Accurate knowledge of embryology is essential for interpretation of congenital cardiac malformations. Recent advances made in the understanding of cardiac development now make it possible to appreciate the morphology of not only the normal heart but also many congenital cardiac malformations. This is true not only for the molecular mechanisms that might lead to the malformations but also for the structure of the normal and abnormally developing heart. In this chapter, we discuss the progress made in demonstrating the structure of the developing heart, along with knowledge of the changes that occur in the expression of the genes and their products, which control the formation and differentiation of its various components.",

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AU - Anderson, Robert H.

AU - Moorman, Antoon F.M.

AU - Brown, Nigel A.

AU - Bamforth, Simon D.

AU - Chaudhry, Bill

AU - Henderson, Deborah J.

AU - Mohun, Timothy J.

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KW - Atrioventricular cushions

KW - Cardiac conduction system

KW - Coronary circulation

KW - Endocardial cushions

KW - Heart tube

KW - Outflow tracts

KW - Sinus venosus

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BT - Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care

PB - Springer-Verlag London Ltd

ER -

Normal and abnormal development of the heart

Abstract

Keywords

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