Notch Signaling: Piercing a Harness of Simplicity

Christina Helbig; Derk Amsen

doi:https://doi.org/10.1016/j.immuni.2015.10.022

Notch Signaling: Piercing a Harness of Simplicity

Christina Helbig, Derk Amsen

Research output: Contribution to journal › Editorial › Academic › peer-review

4 Citations (Scopus)

Abstract

The Notch pathway is an attractive therapeutic target for treatment of cancer and T cell-mediated pathology, but Notch inhibition leads to many side effects. Pinnell et al. (2015) demonstrate that oncogenic functions can be separated biochemically from other functions of Notch, opening new options for more selective targeting of this pathway

Original language	English
Pages (from-to)	831-833
Journal	Immunity
Volume	43
Issue number	5
DOIs	https://doi.org/10.1016/j.immuni.2015.10.022
Publication status	Published - 2015

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https://doi.org/10.1016/j.immuni.2015.10.022

Cite this

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title = "Notch Signaling: Piercing a Harness of Simplicity",

abstract = "The Notch pathway is an attractive therapeutic target for treatment of cancer and T cell-mediated pathology, but Notch inhibition leads to many side effects. Pinnell et al. (2015) demonstrate that oncogenic functions can be separated biochemically from other functions of Notch, opening new options for more selective targeting of this pathway",

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AU - Amsen, Derk

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AB - The Notch pathway is an attractive therapeutic target for treatment of cancer and T cell-mediated pathology, but Notch inhibition leads to many side effects. Pinnell et al. (2015) demonstrate that oncogenic functions can be separated biochemically from other functions of Notch, opening new options for more selective targeting of this pathway

U2 - https://doi.org/10.1016/j.immuni.2015.10.022

DO - https://doi.org/10.1016/j.immuni.2015.10.022

M3 - Editorial

C2 - 26588772

SN - 1074-7613

VL - 43

SP - 831

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JO - Immunity

JF - Immunity

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