TY - JOUR
T1 - Novel Activity-Based Probes for Broad-Spectrum Profiling of Retaining beta-Exoglucosidases In Situ and In Vivo
AU - Kallemeijn, Wouter W.
AU - Li, Kah-Yee
AU - Witte, Martin D.
AU - Marques, André R. A.
AU - Aten, Jan
AU - Scheij, Saskia
AU - Jiang, Jianbing
AU - Willems, Lianne I.
AU - Voorn-Brouwer, Tineke M.
AU - van Roomen, Cindy P. A. A.
AU - Ottenhoff, Roelof
AU - Boot, Rolf G.
AU - van den Elst, Hans
AU - Walvoort, Marthe T. C.
AU - Florea, Bogdan I.
AU - Codée, Jeroen D. C.
AU - van der Marel, Gijsbert A.
AU - Aerts, Johannes M. F. G.
AU - Overkleeft, Herman S.
PY - 2012
Y1 - 2012
N2 - A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational isomers of the cyclophellitol aziridine core may give activity-based probes targeting other retaining glycosidase families
AB - A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational isomers of the cyclophellitol aziridine core may give activity-based probes targeting other retaining glycosidase families
U2 - https://doi.org/10.1002/anie.201207771
DO - https://doi.org/10.1002/anie.201207771
M3 - Article
C2 - 23139194
SN - 0570-0833
VL - 51
SP - 12529
EP - 12533
JO - Angewandte Chemie (International ed. in English)
JF - Angewandte Chemie (International ed. in English)
IS - 50
ER -