Novelties in Brugada Syndrome: Complex Genetics, Risk Stratification, and Catheter Ablation

Wiert F. Hoeksema; Ahmad S. Amin; Connie R. Bezzina; Arthur A. M. Wilde; Pieter G. Postema

doi:https://doi.org/10.1016/j.ccep.2023.05.002

Novelties in Brugada Syndrome: Complex Genetics, Risk Stratification, and Catheter Ablation

Wiert F. Hoeksema, Ahmad S. Amin, Connie R. Bezzina, Arthur A. M. Wilde, Pieter G. Postema

Research output: Contribution to journal › Review article › Academic › peer-review

1 Citation (Scopus)

Abstract

Brugada syndrome (BrS) is an inherited arrhythmia syndrome with distinctive electrocardiographic abnormalities in the right precordial leads and predisposes to ventricular arrhythmias and sudden cardiac death in otherwise healthy patients. Its complex genetic architecture and pathophysiological mechanism are not yet completely understood, and risk stratification remains challenging, particularly in patients at intermediate risk of arrhythmic events. Further understanding of its complex genetic architecture may help improving future risk stratification, and advances in management may contribute to alternatives to implantable cardioverter-defibrillators. Here, the authors review the latest insights and developments in BrS.

Original language	English
Pages (from-to)	273-283
Number of pages	11
Journal	Cardiac Electrophysiology Clinics
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/j.ccep.2023.05.002
Publication status	Published - 1 Sept 2023

Keywords

Brugada syndrome
Sudden cardiac death
Ventricular arrhythmias
Ventricular fibrillation

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https://doi.org/10.1016/j.ccep.2023.05.002

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title = "Novelties in Brugada Syndrome: Complex Genetics, Risk Stratification, and Catheter Ablation",

abstract = "Brugada syndrome (BrS) is an inherited arrhythmia syndrome with distinctive electrocardiographic abnormalities in the right precordial leads and predisposes to ventricular arrhythmias and sudden cardiac death in otherwise healthy patients. Its complex genetic architecture and pathophysiological mechanism are not yet completely understood, and risk stratification remains challenging, particularly in patients at intermediate risk of arrhythmic events. Further understanding of its complex genetic architecture may help improving future risk stratification, and advances in management may contribute to alternatives to implantable cardioverter-defibrillators. Here, the authors review the latest insights and developments in BrS.",

keywords = "Brugada syndrome, Sudden cardiac death, Ventricular arrhythmias, Ventricular fibrillation",

author = "Hoeksema, {Wiert F.} and Amin, {Ahmad S.} and Bezzina, {Connie R.} and Wilde, {Arthur A. M.} and Postema, {Pieter G.}",

note = "Funding Information: Dr P.G. Postema is supported by the Dutch Heart Foundation, Netherlands grant 03-003-2021-T061 . Drs A.A.M. Wilde and C.R. Bezzina are supported by the Dutch Heart Foundation grant 2018-30 PREDICT2 project. Dr C.R. Bezzina acknowledges the support of the EJP-RD project LQTS-NEXT (ZonMW 40–46300–98–19009).",

year = "2023",

month = sep,

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doi = "https://doi.org/10.1016/j.ccep.2023.05.002",

language = "English",

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pages = "273--283",

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T2 - Complex Genetics, Risk Stratification, and Catheter Ablation

AU - Hoeksema, Wiert F.

AU - Amin, Ahmad S.

AU - Bezzina, Connie R.

AU - Wilde, Arthur A. M.

AU - Postema, Pieter G.

N1 - Funding Information: Dr P.G. Postema is supported by the Dutch Heart Foundation, Netherlands grant 03-003-2021-T061 . Drs A.A.M. Wilde and C.R. Bezzina are supported by the Dutch Heart Foundation grant 2018-30 PREDICT2 project. Dr C.R. Bezzina acknowledges the support of the EJP-RD project LQTS-NEXT (ZonMW 40–46300–98–19009).

PY - 2023/9/1

Y1 - 2023/9/1

N2 - Brugada syndrome (BrS) is an inherited arrhythmia syndrome with distinctive electrocardiographic abnormalities in the right precordial leads and predisposes to ventricular arrhythmias and sudden cardiac death in otherwise healthy patients. Its complex genetic architecture and pathophysiological mechanism are not yet completely understood, and risk stratification remains challenging, particularly in patients at intermediate risk of arrhythmic events. Further understanding of its complex genetic architecture may help improving future risk stratification, and advances in management may contribute to alternatives to implantable cardioverter-defibrillators. Here, the authors review the latest insights and developments in BrS.

AB - Brugada syndrome (BrS) is an inherited arrhythmia syndrome with distinctive electrocardiographic abnormalities in the right precordial leads and predisposes to ventricular arrhythmias and sudden cardiac death in otherwise healthy patients. Its complex genetic architecture and pathophysiological mechanism are not yet completely understood, and risk stratification remains challenging, particularly in patients at intermediate risk of arrhythmic events. Further understanding of its complex genetic architecture may help improving future risk stratification, and advances in management may contribute to alternatives to implantable cardioverter-defibrillators. Here, the authors review the latest insights and developments in BrS.

KW - Brugada syndrome

KW - Sudden cardiac death

KW - Ventricular arrhythmias

KW - Ventricular fibrillation

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U2 - https://doi.org/10.1016/j.ccep.2023.05.002

DO - https://doi.org/10.1016/j.ccep.2023.05.002

M3 - Review article

C2 - 37558298

SN - 1877-9182

VL - 15

SP - 273

EP - 283

JO - Cardiac Electrophysiology Clinics

JF - Cardiac Electrophysiology Clinics

IS - 3

ER -

Novelties in Brugada Syndrome: Complex Genetics, Risk Stratification, and Catheter Ablation

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Keywords

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