Abstract
The aim of the current study was to investigate whether alterations in N-terminal pro brain natriuretic peptide (NT-proBNP) reflect changes in right ventricular structure and function in pulmonary hypertension patients during treatment. The study consisted of 30 pulmonary hypertension patients; 15 newly diagnosed and 15 on long-term treatment. NT-proBNP, right heart catheterisation and cardiac magnetic resonance imaging measurements were performed, at baseline and follow-up. There were no significant differences between newly diagnosed patients and those on treatment at baseline or follow-up with respect to NT-proBNP, haemodynamics and right ventricular parameters. Relative changes in NT-proBNP during treatment were correlated to the relative changes in right ventricular end-diastolic volume index (r = 0.59), right ventricular mass index (r = 0.62) and right ventricular ejection fraction (r= -0.81). N-terminal pro brain natriuretic peptide measurements reflect changes in magnetic resonance imaging-measured right ventricular structure and function in pulmonary hypertension patients. An increase in N-terminal pro brain natriuretic peptide over time reflects right ventricular dilatation concomitant to hypertrophy and deterioration of systolic function. Copyright © ERS Journals Ltd 2006.
Original language | English |
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Pages (from-to) | 1190-1194 |
Number of pages | 5 |
Journal | European respiratory journal |
Volume | 28 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 2006 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Biomarkers/blood
- Cardiac Catheterization
- Female
- Humans
- Hypertension, Pulmonary/metabolism
- Hypertrophy, Right Ventricular/metabolism
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Natriuretic Peptide, Brain/blood
- Peptide Fragments/blood
- Prognosis
- Protein Precursors/blood
- Ventricular Dysfunction, Right